Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | membrane integrity is required | Cavia porcellus | |
additional information | membrane integrity is required | Mus musculus | |
additional information | membrane integrity is required | Homo sapiens | |
additional information | membrane integrity is required | Rattus norvegicus | |
additional information | membrane integrity is required | Bos taurus | |
additional information | membrane integrity is required | Equus caballus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a transgenic mouse where O-acetylated GD3 is absent, shows a disruption in organogenesis, suggesting a role for O-acetylated GD3 in cellular differentiation | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CoA | - |
Bos taurus | |
CoA | - |
Equus caballus | |
CoA | - |
Homo sapiens | |
CoA | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0016 | - |
acetyl-CoA | pH 7.0, 37°C | Bos taurus | |
0.0029 | - |
acetyl-CoA | pH 7.0, 22°C | Rattus norvegicus | |
0.0036 | - |
acetyl-CoA | pH 5.6, 30°C | Cavia porcellus | |
0.0061 | - |
acetyl-CoA | pH 7.0, 37°C | Homo sapiens | |
0.0321 | - |
acetyl-CoA | pH 6.6, 37°C | Equus caballus | |
0.0592 | - |
CMP-5-N-acetylneuraminic acid | pH 7.0, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi vesicle | membrane integrity is required | Mus musculus | - |
- |
Golgi vesicle | membrane integrity is required | Homo sapiens | - |
- |
Golgi vesicle | membrane integrity is required | Rattus norvegicus | - |
- |
Golgi vesicle | membrane integrity is required | Bos taurus | - |
- |
Golgi vesicle | membrane integrity is required | Equus caballus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 5-N-acetylneuraminic acid | Cavia porcellus | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | CoA + 5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | Mus musculus | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | CoA + 5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | Rattus norvegicus | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | CoA + 5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | Bos taurus | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | CoA + 5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | Equus caballus | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | CoA + 5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | Cavia porcellus | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | CoA + 5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | Rattus norvegicus | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | CoA + 5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | Bos taurus | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | CoA + 5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | Equus caballus | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | CoA + 5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | Mus musculus | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. in regulation of cancer development via GD3-O-acetylation, overview | CoA + 5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | Cavia porcellus | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | CoA + 5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | Mus musculus | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | CoA + 5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | Rattus norvegicus | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | CoA + 5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | Bos taurus | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | CoA + 5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | Equus caballus | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | CoA + 5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + CMP-5-N-acetylneuraminic acid | Homo sapiens | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | CoA + CMP-5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + CMP-5-N-acetylneuraminic acid | Homo sapiens | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. terminal alpha2,8-linked sialic acid occurs on the glycerol side chain of GD3, where it reverses FAS-mediated apoptotic effects, suggesting a role of GD3 O-acetylation in regulating induced apoptosis, GD2 O-acetylation is oberseved in breast cancer | CoA + CMP-5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + CMP-5-N-acetylneuraminic acid | Homo sapiens | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. via 9-O-acetylation on colonic mucins, overview | CoA + CMP-5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
additional information | Cavia porcellus | Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, one acceptor substrate is GD3, overview | ? | - |
? | |
additional information | Rattus norvegicus | Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview | ? | - |
? | |
additional information | Bos taurus | Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview | ? | - |
? | |
additional information | Equus caballus | Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview | ? | - |
? | |
additional information | Homo sapiens | Golgi O-acetylation pathway, overview, the enzyme is involved in cancer development, enzyme role in regulation, the enzyme colaborates with the sialate O-acetylesterase, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview | ? | - |
? | |
additional information | Mus musculus | Golgi O-acetylation pathway, overview, the enzyme is involved in cancer development, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Cavia porcellus | - |
- |
- |
Equus caballus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
basalioma cell | - |
Homo sapiens | - |
breast cancer cell | - |
Homo sapiens | - |
colon | mucosa | Homo sapiens | - |
colorectal cancer cell | - |
Homo sapiens | - |
liver | - |
Cavia porcellus | - |
liver | - |
Rattus norvegicus | - |
melanoma cell | sialic acid O-acetylation levels in different samples, overview | Homo sapiens | - |
additional information | high expression of O-acetylated GD3 occurs in human basalioma and melanoma | Homo sapiens | - |
skin | sialic acid O-acetylation levels in different samples, overview | Homo sapiens | - |
submandibular gland | - |
Mus musculus | - |
submandibular gland | - |
Bos taurus | - |
submandibular gland | - |
Equus caballus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 5-N-acetylneuraminic acid | - |
Cavia porcellus | CoA + 5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | - |
Mus musculus | CoA + 5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | - |
Rattus norvegicus | CoA + 5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | - |
Bos taurus | CoA + 5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | - |
Equus caballus | CoA + 5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | Cavia porcellus | CoA + 5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | Mus musculus | CoA + 5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | Rattus norvegicus | CoA + 5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | Bos taurus | CoA + 5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | Equus caballus | CoA + 5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | - |
Cavia porcellus | CoA + 5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | - |
Mus musculus | CoA + 5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | - |
Rattus norvegicus | CoA + 5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | - |
Bos taurus | CoA + 5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | - |
Equus caballus | CoA + 5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | Cavia porcellus | CoA + 5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | Rattus norvegicus | CoA + 5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | Bos taurus | CoA + 5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | Equus caballus | CoA + 5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. in regulation of cancer development via GD3-O-acetylation, overview | Mus musculus | CoA + 5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | - |
Cavia porcellus | CoA + 5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | - |
Mus musculus | CoA + 5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | - |
Rattus norvegicus | CoA + 5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | - |
Bos taurus | CoA + 5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | - |
Equus caballus | CoA + 5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | Cavia porcellus | CoA + 5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | Mus musculus | CoA + 5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | Rattus norvegicus | CoA + 5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | Bos taurus | CoA + 5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + 5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | Equus caballus | CoA + 5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + CMP-5-N-acetylneuraminic acid | - |
Homo sapiens | CoA + CMP-5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + CMP-5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes | Homo sapiens | CoA + CMP-5-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + CMP-5-N-acetylneuraminic acid | - |
Homo sapiens | CoA + CMP-5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + CMP-5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. terminal alpha2,8-linked sialic acid occurs on the glycerol side chain of GD3, where it reverses FAS-mediated apoptotic effects, suggesting a role of GD3 O-acetylation in regulating induced apoptosis, GD2 O-acetylation is oberseved in breast cancer | Homo sapiens | CoA + CMP-5-N-acetyl-8-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + CMP-5-N-acetylneuraminic acid | - |
Homo sapiens | CoA + CMP-5-N-acetyl-9-O-acetyl-neuraminate | 9-O-acetyl sialic acids may occur via isomeriaztion of 7-O-acetyl sialic acids | ? | |
acetyl-CoA + CMP-5-N-acetylneuraminic acid | tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. via 9-O-acetylation on colonic mucins, overview | Homo sapiens | CoA + CMP-5-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
additional information | Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, one acceptor substrate is GD3, overview | Cavia porcellus | ? | - |
? | |
additional information | Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview | Rattus norvegicus | ? | - |
? | |
additional information | Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview | Bos taurus | ? | - |
? | |
additional information | Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview | Equus caballus | ? | - |
? | |
additional information | Golgi O-acetylation pathway, overview, the enzyme is involved in cancer development, enzyme role in regulation, the enzyme colaborates with the sialate O-acetylesterase, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview | Homo sapiens | ? | - |
? | |
additional information | Golgi O-acetylation pathway, overview, the enzyme is involved in cancer development, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
7(9)-OAT | - |
Cavia porcellus |
7(9)-OAT | - |
Mus musculus |
7(9)-OAT | - |
Homo sapiens |
7(9)-OAT | - |
Rattus norvegicus |
7(9)-OAT | - |
Bos taurus |
7(9)-OAT | - |
Equus caballus |
sialate-7(9)-O-acetyltransferase | - |
Cavia porcellus |
sialate-7(9)-O-acetyltransferase | - |
Mus musculus |
sialate-7(9)-O-acetyltransferase | - |
Homo sapiens |
sialate-7(9)-O-acetyltransferase | - |
Rattus norvegicus |
sialate-7(9)-O-acetyltransferase | - |
Bos taurus |
sialate-7(9)-O-acetyltransferase | - |
Equus caballus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
- |
Rattus norvegicus |
30 | - |
- |
Cavia porcellus |
37 | - |
- |
Homo sapiens |
37 | - |
- |
Bos taurus |
37 | - |
- |
Equus caballus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.6 | - |
- |
Cavia porcellus |
6.6 | - |
- |
Equus caballus |
7 | - |
- |
Homo sapiens |
7 | - |
- |
Rattus norvegicus |
7 | - |
- |
Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Cavia porcellus | |
acetyl-CoA | - |
Mus musculus | |
acetyl-CoA | - |
Homo sapiens | |
acetyl-CoA | - |
Rattus norvegicus | |
acetyl-CoA | - |
Bos taurus | |
acetyl-CoA | - |
Equus caballus |