Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
an ultra-long-chain fatty acyl-CoA + a sphingoid base | Mus musculus | C26-C34 | an ultra-long-chain ceramide + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skin | the enzyme is expressed in the upper stratum spinosum and stratum granulosumof the skin | Mus musculus | - |
testis | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
an ultra-long-chain fatty acyl-CoA + a sphingoid base | C26-C34 | Mus musculus | an ultra-long-chain ceramide + CoA | - |
? | |
dotriacontanoyl-CoA + sphinganine | - |
Mus musculus | dotriacontanoyl-ceramide + CoA | - |
? | |
hexacosanoyl-CoA + sphinganine | - |
Mus musculus | hexacosanoyl ceramide + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CerS3 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme mutations are associated with skin ichthyosis. Enzyme-deficient mice show death after birth due to transepidermal water loss, hyperkeratosis, deficient cornification, and increased susceptibility to Candida albicans infection | Mus musculus |