Organism | UniProt | Comment | Textmining |
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Streptomyces spectabilis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrobenzoyl-CoA + malonyl-CoA + 6 (S)-methylmalonyl-CoA + 6 NADPH + 4 H+ | - |
Streptomyces spectabilis | demethyldeoxyspectinabilin + 7 CO2 + 8 CoA + 6 NADP+ + 5 H2O | - |
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General Information | Comment | Organism |
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physiological function | the polyketidsynthase system consists of 4 subunits. SpnA is an iterative modular type I polyketide synthase. Six PKS modules of the spectinabilin cluster catalyze seven rounds of elongation and reduction. SpnA' is a biomodular protein of the same domain architecture of SpnA (ketosynthase, acyl transferase, dehydratase, ketoreductase and acyl carrier protein), which is responsible for two successive unsaturated chain elongation steps using methylmalonyl-CoA. SpnB contains a sequence of malonyl-CoA specificity in the AT domain, which leads to a full reduction of the beta-keto group after condensation of malonyl-coA.7 SpnC carries two modules of ketosynthase, acyl transferase, and acyl carrier protein domains and a C-terminal thioesterase domain and catalyzes the last two Claisen condensations | Streptomyces spectabilis |