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Literature summary for 2.3.1.286 extracted from
- Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins (2013), J. Biol. Chem., 288, 31350-31356.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NAD+ + [protein]-N6-succinyl-L-lysine | Homo sapiens | - |
nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q8IXJ6 | - |
- |
| Homo sapiens | Q96EB6 | - |
- |
| Homo sapiens | Q9NTG7 | - |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| [protein]-N6-acetyl-L-lysine + NAD+ + H2O = [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | broad specificity with respect to chain length of the acyl chain | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no activity with the crotonylated histone H3 peptide QTAR(N6-crotonyl)KSTGG | Homo sapiens | ? | - |
? | |
| additional information | no activity with the succinylated histone H3 peptide QTAR(N6-succinyl)KSTGG | Homo sapiens | ? | - |
? | |
| NAD+ + QTAR(N6-acetyl)KSTGG | acetylated histone H3 peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-acetyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-butyryl)KSTGG | butyrylated histone H3 peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-butyryl)KSTGG | butyrylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-butyryl)KSTGG | butyrylated histone H3 peptide, about 5% compared to the activity with the acetylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-crotonyl)KSTGG | crotonylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-crotonyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-crotonyl)KSTGG | crotonylated histone H3 peptide, about 30% compared to the activity with the acetylated or hexanoylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-crotonyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-decanoyl)KSTGG | decanoylated histone H3 peptide, about 50% compared to the activity with the acetylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-decanoyl)KSTGG | decanoylated histone H3 peptide, about 65% compared to the activity with the acetylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-decanoyl)KSTGG | decanoylated histone H3 peptide, about 80% compared to the activity with the acetylated or hexanoylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-decanoyl)KSTGG | myristoylated histone H3 peptide, about 50% compared to the activity with the acetylated or hexanoylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-decanoyl)KSTGG | myristoylated histone H3 peptide, about 65% compared to the activity with the acetylated or hexanoylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-dodecanoyl)KSTGG | dodecanoylated histone H3 peptide, about 30% compared to the activity with the acetylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-dodecanoyl)KSTGG | dodecanoylated histone H3 peptide, about 60% compared to the activity with the acetylated or hexanoylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-dodecanoyl)KSTGG | dodecanoylated histone H3 peptide, about 65% compared to the activity with the acetylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-hexanoyl)KSTGG | hexanoylated histone H3 peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-hexanoyl)KSTGG | hexanoylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-hexanoyl)KSTGG | hexanoylated histone H3 peptide, about 40% compared to the activity with the acetylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-myristoyl)KSTGG | myristoylated histone H3 peptide, about 45% compared to the activity with the acetylated or hexanoylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-myristoyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-octanoyl)KSTGG | octanoylated histone H3 peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-octanoyl)KSTGG | octanoylated histone H3 peptide, about 35% compared to the activity with the acetylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-octanoyl)KSTGG | octanoylated histone H3 peptide, about 55% compared to the activity with the acetylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-palmitoyl)KSTGG | myristoylated histone H3 peptide, about 30% compared to the activity with the acetylated or hexanoylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-palmitoyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-propionyl)KSTGG | propionylated histone H3 peptide, about 10% compared to the activity with the acetylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-propionyl)KSTGG | propionylated histone H3 peptide, about 40% compared to the activity with the acetylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-propionyl)KSTGG | propionylated histone H3 peptide, about 60% compared to the activity with the acetylated or hexanoylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose | - |
? | |
| NAD+ + QTAR(N6-succinyl)KSTGG | succinylated histone H3 peptide, about 10% compared to the activity with the acetylated peptide | Homo sapiens | nicotinamide + QTARKSTGG + 2'-O-succinyl-ADP-ribose | - |
? | |
| NAD+ + [protein]-N6-succinyl-L-lysine | - |
Homo sapiens | nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SIRT1 | - |
Homo sapiens |
| SIRT2 | - |
Homo sapiens |
| SIRT3 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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