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Literature summary for 2.3.1.22 extracted from

  • Liss, K.H.H.; Lutkewitte, A.J.; Pietka, T.; Finck, B.N.; Franczyk, M.; Yoshino, J.; Klein, S.; Hall, A.M.
    Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans (2018), J. Lipid Res., 59, 1630-1639 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.22

Application

Application Comment Organism
medicine expression of MGAT1 is robustly induced during adipocyte differentiation and its expression is suppressed in fat of genetically-obese mice Mus musculus
medicine expression of MGAT1 is robustly induced during adipocyte differentiation and its expression is suppressed in metabolically abnormal obese human subjects Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96PD6 isoform Mogat1
-
Mus musculus Q91ZV4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Mus musculus
-
adipocyte
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
MGAT1
-
 Mus musculus
MGAT1
-
 Homo sapiens
MOGAT1
-
 Mus musculus
MOGAT1
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus expression of MGAT1 is robustly induced during adipocyte differentiation and its expression is suppressed in fat of genetically-obese mice up
Homo sapiens expression of MGAT1 is robustly induced during adipocyte differentiation and its expression is suppressed in metabolically abnormal obese human subjects up

General Information

General Information Comment Organism
physiological function MGAT1 expression is reduced in physiologic contexts where lipolysis is high. Knockdown or knockout of MGAT1 in adipocytes leads to higher rates of basal adipocyte lipolysis Mus musculus