Literature summary for 2.3.1.22 extracted from

Lee, Y.J.; Kim, J.W.
Monoacylglycerol O-acyltransferase 1 (MGAT1) localizes to the ER and lipid droplets promoting triacylglycerol synthesis (2017), BMB Rep., 50, 367-372 .

Search for more literature for 2.3.1.22

Protein Variants

Protein Variants	Comment	Organism
additional information	mutant FL-DELTA1-160, with both transmembrane regions deleted, displays relocation in the cytosol. Mutant FL-DELTA161-335, which contains the N-terminus and the two transmembrane domains, exists in the membrane fraction	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	MGAT1 localizes to the endoplasmic reticulum under normal conditions, and colocalizes to lipid droplets under conditions of enriching fatty acids, contributing to TAG synthesis and LD expansion	Mus musculus	5783	-
lipid droplet	MGAT1 localizes to the endoplasmic reticulum under normal conditions, and colocalizes to lipid droplets under conditions of enriching fatty acids, contributing to TAG synthesis and LD expansion	Mus musculus	5811	-
membrane	for the enzyme activity, both the N-terminal transmembrane domain and catalytic HPHG motif are required. The transmembrane domain consists of two hydrophobic regions in the N-terminus, the consensus sequence FLXLXXXn, a putative neutral lipid-binding domain, exists in the first transmembrane domain	Mus musculus	16020	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q91ZV4	-	-

Synonyms

Synonyms	Comment	Organism
MGAT1	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	MGAT1 interacts with DGAT2, which serves to synergistically increase the TAG biosynthesis and lipid droplet expansion, leading to enhancement of lipid accumulation in the liver and fat	Mus musculus

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Release 2023.1 (January 2023)