BRENDA - Enzyme Database
show all sequences of 2.3.1.176

The sterol carrier protein 2/3-oxoacyl-CoA thiolase (SCPx) is involved in cholesterol uptake in the midgut of Spodoptera litura: Gene cloning, expression, localization and functional analyses

Guo, X.; Zheng, S.; Liu, L.; Feng, Q.; BMC Mol. Biol. 10, 0000 (2009)
No PubMed abstract available

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
-
Spodoptera litura
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Spodoptera litura
5737
-
nucleus
-
Spodoptera litura
5634
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
16000
-
x * 16000, SDS-PAGE
Spodoptera litura
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Spodoptera litura
D1GJ60
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
epidermis
-
Spodoptera litura
-
fat body
-
Spodoptera litura
-
midgut
-
Spodoptera litura
-
Subunits
Subunits
Commentary
Organism
?
x * 16000, SDS-PAGE
Spodoptera litura
Cloned(Commentary) (protein specific)
Commentary
Organism
-
Spodoptera litura
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Spodoptera litura
5737
-
nucleus
-
Spodoptera litura
5634
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
16000
-
x * 16000, SDS-PAGE
Spodoptera litura
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
epidermis
-
Spodoptera litura
-
fat body
-
Spodoptera litura
-
midgut
-
Spodoptera litura
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 16000, SDS-PAGE
Spodoptera litura
General Information
General Information
Commentary
Organism
physiological function
overexpression enhances cholesterol uptakeinto Spli-221 cells
Spodoptera litura
General Information (protein specific)
General Information
Commentary
Organism
physiological function
overexpression enhances cholesterol uptakeinto Spli-221 cells
Spodoptera litura
Other publictions for EC 2.3.1.176
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735407
Cheng
Synthesis, purification and cr ...
Homo sapiens
Acta Crystallogr. Sect. F
71
901-905
2015
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1
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3
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736620
Fu
Sterol carrier protein 2, a cr ...
Aedes aegypti
J. Med. Entomol.
52
1124-1134
2015
-
1
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1
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4
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737254
Ma
NMR structure and function of ...
Helicoverpa armigera
Sci. Rep.
5
18186
2015
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1
1
8
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2
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1
1
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735998
Cerqueira
Sterol carrier protein 2 regul ...
Xenopus laevis
Dev. Biol.
394
54-64
2014
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1
1
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736836
Liedhegner
Sterol carrier protein-2: bind ...
Homo sapiens
Mol. Neurobiol.
50
149-158
2014
-
1
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-
-
-
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-
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-
-
-
1
-
-
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1
1
-
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720169
Du
Characterization of the sterol ...
Helicoverpa armigera
J. Insect Physiol.
58
1413-1423
2012
-
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1
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-
2
-
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-
-
-
-
4
-
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7
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7
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3
3
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719181
Kim
Sterol carrier protein-x gene ...
Manduca sexta
BMC Physiol.
10
9
2010
-
1
1
-
-
-
-
-
-
-
-
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7
-
-
-
-
-
3
-
-
1
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1
2
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6
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1
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2
3
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702910
Guo
-
The sterol carrier protein 2/3 ...
Spodoptera litura
BMC Mol. Biol.
10
0000
2009
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1
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2
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1
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1
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1
1
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704999
Atshaves
Overexpression of sterol carri ...
Mus musculus
J. Lipid Res.
50
1429-1447
2009
-
1
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1
-
-
-
-
-
-
-
-
3
-
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702239
Martin
Structure and function of the ...
Homo sapiens
Biochemistry
47
5915-5934
2008
-
-
1
-
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-
2
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1
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705463
McIntosh
Structure of dehydroergosterol ...
Homo sapiens
Lipids
43
1165-1184
2008
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
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685342
Schroeder
Sterol carrier protein-2: new ...
Mus musculus
Biochim. Biophys. Acta
1771
700-718
2007
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1
1
1
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2
-
2
1
-
2
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1
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5
-
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1
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1
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2
1
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1
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5
-
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662092
Falany
Glycine and taurine conjugatio ...
Homo sapiens
J. Biol. Chem.
269
19375-19379
1994
-
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-
-
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-
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1
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1
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662586
Kase
Formation of cholic acid from ...
Rattus norvegicus
J. Lipid Res.
24
1560-1567
1983
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-
-
-
-
-
1
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-
-
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1
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661716
Pedersen
Conversion of 3alpha,7alpha,12 ...
Rattus norvegicus
FEBS Lett.
121
345-348
1980
-
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1
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1
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