Protein Variants | Comment | Organism |
---|---|---|
additional information | disruption of the aatA gene reduces penicillin production to 20%, the remaining activity is attributed to the product of gene aatB | Aspergillus nidulans |
additional information | Overexpression of a mutated aatB-PTS1 gene in an aatA-disruption strain, leading to peroxisomal localization of AatB, increased the penicillin titre more than overexpression of the wild-type aatB. | Aspergillus nidulans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | IAT encoded by the aatB gene, lacking a peroxisomal targeting signal PTS1 | Aspergillus nidulans | 5737 | - |
peroxisome | IAT encoded by the aatA gene, containing a peroxisomal targeting signal PTS1 | Aspergillus nidulans | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus nidulans | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
aatA | - |
Aspergillus nidulans |
aatA | gene encoding isopenicillin N acyltransferase | Aspergillus nidulans |
aatB | - |
Aspergillus nidulans |
aatB | AN6775.3, gene encoding a penicillin V producing activity, which, in contrast to aatA, does not encode a peroxisomal targeting signal PTS1. aatB homologues also exist in non-penicillin-producing fungi and is suggested to be a paralogue of aatA. | Aspergillus nidulans |
acyl-coenzyme A: IPN acyltransferase | - |
Aspergillus nidulans |
IAT | - |
Aspergillus nidulans |
isopenicillin N acyltransferase | - |
Aspergillus nidulans |
Organism | Comment | Expression |
---|---|---|
Aspergillus nidulans | transcription factor AnBH1 acting as a repressor of aatA and aatB expression | down |
Aspergillus nidulans | transcription factor AnCF acting as an activator of aatA and aatB expression | up |
General Information | Comment | Organism |
---|---|---|
metabolism | catalyses final step of penicillin biosynthesis | Aspergillus nidulans |