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Literature summary for 2.3.1.164 extracted from

  • Sproete, P.; Hynes, M.J.; Hortschansky, P.; Shelest, E.; Scharf, D.H.; Wolke, S.M.; Brakhage, A.A.
    Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster (2008), Mol. Microbiol., 70, 445-461.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information disruption of the aatA gene reduces penicillin production to 20%, the remaining activity is attributed to the product of gene aatB Aspergillus nidulans
additional information Overexpression of a mutated aatB-PTS1 gene in an aatA-disruption strain, leading to peroxisomal localization of AatB, increased the penicillin titre more than overexpression of the wild-type aatB. Aspergillus nidulans

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm IAT encoded by the aatB gene, lacking a peroxisomal targeting signal PTS1 Aspergillus nidulans 5737
-
peroxisome IAT encoded by the aatA gene, containing a peroxisomal targeting signal PTS1 Aspergillus nidulans 5777
-

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
-
-

Synonyms

Synonyms Comment Organism
aatA
-
Aspergillus nidulans
aatA gene encoding isopenicillin N acyltransferase Aspergillus nidulans
aatB
-
Aspergillus nidulans
aatB AN6775.3, gene encoding a penicillin V producing activity, which, in contrast to aatA, does not encode a peroxisomal targeting signal PTS1. aatB homologues also exist in non-penicillin-producing fungi and is suggested to be a paralogue of aatA. Aspergillus nidulans
acyl-coenzyme A: IPN acyltransferase
-
Aspergillus nidulans
IAT
-
Aspergillus nidulans
isopenicillin N acyltransferase
-
Aspergillus nidulans

Expression

Organism Comment Expression
Aspergillus nidulans transcription factor AnBH1 acting as a repressor of aatA and aatB expression down
Aspergillus nidulans transcription factor AnCF acting as an activator of aatA and aatB expression up

General Information

General Information Comment Organism
metabolism catalyses final step of penicillin biosynthesis Aspergillus nidulans