Any feedback?
Literature summary for 2.3.1.105 extracted from
- A new de novo pathway for the formation of 1-alkyl-2-acetyl-sn-glycerols, precursors of platelet activating factor. Biochemical characterization of 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase in rat spleen (1986), J. Biol. Chem., 261, 5373-5377.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Sodium vanadate | inhibits at concentrations above 0.025 mM | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.226 | - |
acetyl-CoA | apparent Km at pH 8.4 and 23°C | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Na+ | 50 nM NaF increases the synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphate | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate | Rattus norvegicus | involved in biosynthesis of thrombocyte activating factor in animal tissue | CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
| renal cortex | - |
Rattus norvegicus | - |
| renal medulla | - |
Rattus norvegicus | - |
| spleen | highest activity | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate | - |
Rattus norvegicus | CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate | - |
? | |
| acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate | involved in biosynthesis of thrombocyte activating factor in animal tissue | Rattus norvegicus | CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.4 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 8.8 | - |
Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
