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Literature summary for 2.1.3.2 extracted from

  • Lunev, S.; Bosch, S.S.; Batista, F.A.; Wang, C.; Li, J.; Linzke, M.; Kruithof, P.; Chamoun, G.; Doemling, A.S.S.; Wrenger, C.; Groves, M.R.
    Identification of a non-competitive inhibitor of Plasmodium falciparum aspartate transcarbamoylase (2018), Biochem. Biophys. Res. Commun., 497, 835-842 .
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Plasmodium falciparum

Crystallization (Commentary)

Crystallization (Comment) Organism
full-length enzyme, sitting drop vapor diffusion method, using 0.2 M potassium citrate tribasic monohydrate, 20% (w/v) PEG 3350. Enzyme in complex with 2,3-naphthalenediol, hanging drop vapor diffusion method, 0.1 M bis-Tris propane pH 7.5, 0.2 M Na2SO4, 15% (w/v) PEG 3350 Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
1,4,6,7-tetrabromo-2,3-naphthalenediol
-
 Plasmodium falciparum
2,3-naphthalenediol non-competitive inhibitor Plasmodium falciparum
2-amino-3-naphthol
-
 Plasmodium falciparum
2-naphthol
-
 Plasmodium falciparum
4-tert-butylcatechol
-
 Plasmodium falciparum
6,7-dibromo-2,3-naphthalenediol
-
 Plasmodium falciparum
6-bromo-2-naphthol
-
 Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
carbamoyl phosphate + L-aspartate Plasmodium falciparum
-
 phosphate + N-carbamoyl-L-aspartate
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum O15804
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + L-aspartate
-
 Plasmodium falciparum phosphate + N-carbamoyl-L-aspartate
-
 ?

Synonyms

Synonyms Comment Organism
aspartate transcarbamoylase
-
 Plasmodium falciparum
ATC
-
 Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0022
-
 at pH 8.0 and 45°C Plasmodium falciparum 1,4,6,7-tetrabromo-2,3-naphthalenediol
0.0055
-
 at pH 8.0 and 45°C Plasmodium falciparum 2,3-naphthalenediol
0.0146
-
 at pH 8.0 and 45°C Plasmodium falciparum 6,7-dibromo-2,3-naphthalenediol
0.016
-
 at pH 8.0 and 45°C Plasmodium falciparum 2-naphthol
0.0176
-
 at pH 8.0 and 45°C Plasmodium falciparum 6-bromo-2-naphthol
0.031
-
 at pH 8.0 and 45°C Plasmodium falciparum 4-tert-butylcatechol
0.185
-
 at pH 8.0 and 45°C Plasmodium falciparum 2-amino-3-naphthol