Cloned (Comment) | Organism |
---|---|
second GAR transformylase encoded by the Escherichia coli purT gene | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0123 | - |
10-formyl-5,8-dideazafolate | - |
Escherichia coli | |
0.019 | - |
5,8-Dideazafolate | - |
Escherichia coli | |
0.102 | - |
formyl-beta-glycinamide ribonucleotide | - |
Escherichia coli | |
0.118 | - |
beta-glycinamide ribonucleotide | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Homo sapiens | - |
tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Mus musculus | third step in de novo purine biosynthetic pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Escherichia coli | third step in de novo purine biosynthetic pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Homo sapiens | - |
human | - |
Mus musculus | - |
mouse | - |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Mus musculus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Escherichia coli | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
r | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Homo sapiens | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | third step in de novo purine biosynthetic pathway | Mus musculus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | third step in de novo purine biosynthetic pathway | Escherichia coli | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
r | |
acetate + ATP | novel non-folate glycinamide ribonucleotide transformylase purT gene product, no significant homology to known EC 2.1.2.2 but significant homology to the purK protein also involved in purine biosynthesis | Escherichia coli | acetyl phosphate + ADP | - |
? | |
additional information | trifunctional enzyme, GAR synthetase, aminoimidazole ribonucleotide synthetase and GAR transformylase | Mus musculus | ? | - |
? | |
additional information | trifunctional enzyme, GAR synthetase, aminoimidazole ribonucleotide synthetase and GAR transformylase | Homo sapiens | ? | - |
? |