Protein Variants | Comment | Organism |
---|---|---|
D83V | inactive | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein L-isoaspartate | Homo sapiens | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HUVEC cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Homo sapiens | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
L-isoaspartyl (D-aspartyl) methyltransferase | - |
Homo sapiens |
PIMT | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme down-regulation in HUVEC cells inhibits both cell migration and tube formation in vitro when stimulated by vascular endothelial growth factor | Homo sapiens |
physiological function | the enzyme is required for vascular endothelial growth factor-dependent endothelial cell migration and tubulogenesis. Enzyme overexpression promotes angiogenic properties in HUVEC cells | Homo sapiens |