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Literature summary for 2.1.1.67 extracted from

  • Stocco, G.; Crews, K.R.; Evans, W.E.
    Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status (2010), Expert. Opin. Drug Saf., 9, 23-37.
    View publication on PubMed
Search for more literature for 2.1.1.67

Application

Application Comment Organism
medicine mercaptopurine dose can be adjusted on the basis of TPMT genotype to mitigate toxicity in pediatric patients with acute lymphoblastic leukemia Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + thioinosine monophosphate
-
 Homo sapiens S-adenosyl-L-homocysteine + methylthioinosine monophosphate
-
 ?
S-adenosyl-L-methionine + thioinosine triphosphate
-
 Homo sapiens S-adenosyl-L-homocysteine + methylthioinosine triphosphate
-
 ?

Synonyms

Synonyms Comment Organism
thiopurine-S-methyl-transferase
-
 Homo sapiens
TPMT
-
 Homo sapiens