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Literature summary for 2.1.1.67 extracted from

  • Tumer, T.B.; Ulusoy, G.; Adali, O.; Sahin, G.; Gozdasoglu, S.; Arinc, E.
    The low frequency of defective TPMT alleles in Turkish population: a study on pediatric patients with acute lymphoblastic leukemia (2007), Am. J. Hematol., 82, 906-910.
    View publication on PubMed
Search for more literature for 2.1.1.67

Application

Application Comment Organism
medicine patients carrying defective mutations in TMPT gene have elevated thioguanine nucleotides concentrations that finally result in severe or even fatal hematopoietic toxicities when they are treated with standard doses of 6-mercaptopurine Homo sapiens

Protein Variants

Protein Variants Comment Organism
TPMT*2 polymorphism, single nucleotide substitution G238C, inactivating mutation Homo sapiens
TPMT*3B polymorphism, single nucleotide substitution G460A, inactivating mutation Homo sapiens
TPMT*3C polymorphism, single nucleotide substitution A719G, inactivating mutation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Synonyms

Synonyms Comment Organism
thiopurine methyltransferase
-
 Homo sapiens
TPMT
-
 Homo sapiens