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Literature summary for 2.1.1.67 extracted from
- Thiopurine methyltransferase isozymes in human renal tissue (1990), Drug Metab. Dispos., 18, 632-638.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3,4-dimethoxy-5-hydroxybenzoic acid | - |
Homo sapiens |  |
| 6-Mercaptopurine | - |
Homo sapiens | |
| benzoic acid | benzoic acid derivatives | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00637 | - |
S-adenosyl-L-methionine | isoenzyme II | Homo sapiens | |
| 0.00722 | - |
S-adenosyl-L-methionine | isoenzyme I | Homo sapiens | |
| 0.224 | - |
6-Mercaptopurine | isoenzyme II | Homo sapiens | |
| 0.307 | - |
6-Mercaptopurine | isoenzyme I | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| cytoplasm | - |
Mus musculus | 5737 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 30000 | - |
2 isozymes, gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + a thiopurine | Mus musculus | - |
S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? | |
| S-adenosyl-L-methionine + a thiopurine | Homo sapiens | - |
S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
| Mus musculus | - |
mouse | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 2 isozymes | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Homo sapiens | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Mus musculus | - |
| lymphocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + 6-mercaptopurine | - |
Mus musculus | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
| S-adenosyl-L-methionine + 6-mercaptopurine | immunosuppressant medication | Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
| S-adenosyl-L-methionine + 6-thioguanine | - |
Mus musculus | S-adenosyl-L-homocysteine + 6-methylthioguanine | - |
? | |
| S-adenosyl-L-methionine + 6-thioguanine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylthioguanine | - |
? | |
| S-adenosyl-L-methionine + a thiopurine | - |
Mus musculus | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? | |
| S-adenosyl-L-methionine + a thiopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00802 | - |
6-Mercaptopurine | isoenzyme II | Homo sapiens | |
| 0.0107 | - |
3,4-dimethoxy-5-hydroxybenzoic acid | isoenzyme II | Homo sapiens | |
| 0.0113 | - |
3,4-dimethoxy-5-hydroxybenzoic acid | isoenzyme I | Homo sapiens | |
| 0.0113 | - |
6-Mercaptopurine | isoenzyme I | Homo sapiens | |
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