Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DNA | - |
Homo sapiens | |
DNA | - |
Mus musculus | |
Na2SO4 | - |
Homo sapiens | |
Na2SO4 | - |
Mus musculus | |
Na3 citrate | - |
Homo sapiens | |
Na3 citrate | - |
Mus musculus | |
NaCl | 0.2 M, 80% inhibition | Homo sapiens | |
NaCl | 0.2 M, wild-type and mutant enzyme, 55% inhibition | Mus musculus | |
RNA | - |
Homo sapiens | |
RNA | - |
Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
20900 | - |
x * 20900, SDS-PAGE | Homo sapiens |
22500 | - |
x * 22500, SDS-PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA containing 6-O-methylguanine + [protein]-L-cysteine | Mus musculus | the enzyme repairs mutagenic and carcinogenic 6-O-alkylguanine in DNA | DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine | - |
? | |
DNA containing 6-O-methylguanine + [protein]-L-cysteine | Homo sapiens | the enzyme repairs mutagenic and carcinogenic 6-O-alkylguanine in DNA | DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA containing 6-O-methylguanine + [protein]-L-cysteine | enzyme reacts with the alkylated base in a synthetic DNA substrate poly(dC, dG, m6dG) | Mus musculus | DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine | - |
? | |
DNA containing 6-O-methylguanine + [protein]-L-cysteine | enzyme reacts with the alkylated base in a synthetic DNA substrate poly(dC, dG, m6dG) | Homo sapiens | DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine | - |
? | |
DNA containing 6-O-methylguanine + [protein]-L-cysteine | the enzyme repairs mutagenic and carcinogenic 6-O-alkylguanine in DNA | Mus musculus | DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine | - |
? | |
DNA containing 6-O-methylguanine + [protein]-L-cysteine | the enzyme repairs mutagenic and carcinogenic 6-O-alkylguanine in DNA | Homo sapiens | DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 20900, SDS-PAGE | Homo sapiens |
? | x * 22500, SDS-PAGE | Mus musculus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
20 min, 55-65% loss of activity in absence of DNA, 25-35% loss of activity in presence of DNA, 0.2 mg/ml | Mus musculus |
50 | - |
20 min, 55-65% loss of activity in absence of DNA, 25-35% loss of activity in presence of DNA, 0.2 mg/ml | Homo sapiens |