Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-isosalsoline + methyl group donor | Bos taurus | - |
N-methyl-(R)-isosalsoline + demethylated methyl group donor | N-methyl-(R)-isosalsoline is enzymatically formed in liver and can be transported into the brain from blood, it may act as neurotransmitter | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
amine N-methyltransferase A | - |
Purification (Comment) | Organism |
---|---|
amine N-methyltransferase A | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0000012 | - |
N-methyltransferase A, (-)-(S)-isosalsoline | Bos taurus |
0.0000021 | - |
N-methyltransferase A, (-)-(S)-salsolidine | Bos taurus |
0.0000033 | - |
N-methyltransferase A, (+)-(R)-isosalsoline | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-isosalsoline + methyl group donor | - |
Bos taurus | N-methyl-(R)-isosalsoline + demethylated methyl group donor | N-methyl-(R)-isosalsoline is enzymatically formed in liver and can be transported into the brain from blood, it may act as neurotransmitter | ? | |
S-adenosyl-L-methionine + 1,2,3,4-tetrahydroisoquinoline | amine N-methyltransferase A | Bos taurus | S-adenosyl-L-homocysteine + N-methyl-1,2,3,4-tetrahydroisoquinoline | - |
? | |
S-adenosyl-L-methionine + isosalsoline | isosalsoline is identical with 7-hydroxy-6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline, stereospecific N-methylation by amine N-methyltransferase A, (+)-(R)-enantiomer is preferentially methylated | Bos taurus | S-adenosyl-L-homocysteine + N-methylisosalsoline | - |
? | |
S-adenosyl-L-methionine + salsolidine | salsolidine is identical with 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline, stereospecific N-methylation by amine N-methyltransferase A, (-)-(S)-enantiomer is preferentially methylated | Bos taurus | S-adenosyl-L-homocysteine + N-methylsalsolidine | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Bos taurus |