Crystallization (Comment) | Organism |
---|---|
enzyme crystal structure, PDB ID 4A6E, analysis and structure modeling | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + N-acetylserotonin | Homo sapiens | - |
S-adenosyl-L-homocysteine + melatonin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P46597 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin | modeling of the catalytic mechanism | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + N-acetylserotonin | - |
Homo sapiens | S-adenosyl-L-homocysteine + melatonin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ASMT | - |
Homo sapiens |
HIOMT | - |
Homo sapiens |
hydroxyindole O-methyltransferase | - |
Homo sapiens |
N-acetylserotonin methyltransferase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to S-adenosyl-L-methionine dependent animal natural product O-methyltransferase | Homo sapiens |
malfunction | lack of melatonin is a risk signal and will result in diabetes, psychiatric disorders, and other diverse medical conditions | Homo sapiens |
metabolism | ASMT is a key enzyme to catalyse the terminal step of melatonin (N-acetyl-5-methoxytryptamine) | Homo sapiens |
additional information | roles of several residues around the active sites and methyl-transfer mechanism of human N-acetylserotonin methyltransferase, density function theory method, overview. residues H255, D256, E311, and R252 play an important role in reducing the barrier height and inducing methyl transfer. Some residues around the SAM in the centre of active site are essential factors to influence the mechanism and barrier height | Homo sapiens |
physiological function | ASMT is a key enzyme to catalyse the terminal step of melatonin (N-acetyl-5-methoxytryptamine). Melatonin is related with various physiological functions, such as sleep induction, circadian rhythm regulation together with oxidative stress and immune response | Homo sapiens |