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Literature summary for 2.1.1.355 extracted from

  • Casciello, F.; Windloch, K.; Gannon, F.; Lee, J.S.
    Functional role of G9a histone methyltransferase in cancer (2015), Front. Immunol., 6, 487 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.355

Inhibitors

Inhibitors Comment Organism Structure
BIX-01294 diazepin-quinazolin-amine derivative, specific competitive inhibitor Mus musculus
UNC0638
-
 Mus musculus
UNC0642
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Mus musculus overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 r
additional information Mus musculus the enzyme is automethylated at K239 ?
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
 r
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 r
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 r
S-adenosyl-L-methionine + ACINUS Mus musculus
-
 ?
-
 ?
S-adenosyl-L-methionine + CDYL1 Mus musculus
-
 ?
-
 ?
S-adenosyl-L-methionine + p53 Mus musculus the enzyme is responsible for p53 methylation at lysine 373 ?
-
 ?
S-adenosyl-L-methionine + reptin Mus musculus the enzyme is responsible for reptin methylation at lysine 67 ?
-
 ?
S-adenosyl-L-methionine + WIZ Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9Z148
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 overall reaction Mus musculus 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 r
additional information the enzyme is automethylated at K239 Mus musculus ?
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine9
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
 r
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 r
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 r
S-adenosyl-L-methionine + ACINUS
-
 Mus musculus ?
-
 ?
S-adenosyl-L-methionine + CDYL1
-
 Mus musculus ?
-
 ?
S-adenosyl-L-methionine + p53 the enzyme is responsible for p53 methylation at lysine 373 Mus musculus ?
-
 ?
S-adenosyl-L-methionine + reptin the enzyme is responsible for reptin methylation at lysine 67 Mus musculus ?
-
 ?
S-adenosyl-L-methionine + WIZ
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
EHMT2
-
 Mus musculus
G9a
-
 Mus musculus
H3K9 methyltransferase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus the enzyme is overexpressed in a number of cancers, including esophageal squamous cell carcinoma, hepato-cellular carcinoma, aggressive lung cancer, brain cancer, multiple myeloma, and aggressive ovarian carcinoma up

General Information

General Information Comment Organism
malfunction enzyme depletion results in embryonic lethality with severe differentiation defects in embryonic stem cells. Enzyme depletion inhibits cell proliferation in several cancer cell lines Mus musculus
physiological function the enzyme is essential for the repression of developmental genes and is required during development Mus musculus