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Literature summary for 2.1.1.348 extracted from

  • Huang, J.; Dong, X.; Gong, Z.; Qin, L.; Yang, S.; Zhu, Y.; Wang, X.; Zhang, D.; Zou, T.; Yin, P.; Tang, C.
    Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase (2018), Protein Cell, 10, 272-284.
    View publication on PubMedView publication on EuropePMC
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Crystallization (Commentary)

Crystallization (Comment) Organism
solution structure for the zinc finger domain of catalytic subunit METTL3. The zinc finger domain specifically binds to an RNA containing 5'-GGACU-3' consensus sequence. The zinc finger domain contains two CCCH-type zinc fingers connected by an anti-parallel beta-sheet. The RNA-binding interface comprises basic residues from zinc finger 1 and hydrophobic residues from beta-sheet and zinc finger 2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86U44 and Q9HCE5 Q86U44 i.e. catalytic subunit METTL3, Q9HCE5 i.e non-catalytic subunit METTL14
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Synonyms

Synonyms Comment Organism
METTL14
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 Homo sapiens
METTL3
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 Homo sapiens
N6-adenosine-methyltransferase
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 Homo sapiens