Literature summary for 2.1.1.348 extracted from

Schwartz, S.; Mumbach, M.R.; Jovanovic, M.; Wang, T.; Maciag, K.; Bushkin, G.G.; Mertins, P.; Ter-Ovanesyan, D.; Habib, N.; Cacchiarelli, D.; Sanjana, N.E.; Freinkman, E.; Pacold, M.E.; Satija, R.; Mikkelsen, T.S.; Hacohen, N.; Zhang, F.; Carr, S.A.; Lander, E.S.; Regev, A.
Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5 sites (2014), Cell Rep., 8, 284-296 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK-293 cell	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q86U44 and Q9HCE5	Q86U44 i.e. catalytic subunit METTL3, Q9HCE5 i.e non-catalytic subunit METTL14	-

General Information

General Information	Comment	Organism
physiological function	catalytic subunit METTL3 interacts in a dense network of proteins. Presence of WTAP (Wilms' tumor associated protein), METTL14 and protein KIAA1429 are required for methylation. WTAP-dependent methylation sites are located at internal positions in transcripts, are topologically static across a variety of systems, and are inversely correlated with mRNA stability. WTAP-independent sites form at the first transcribed base as part of the cap structure, and are present at thousands of sites, forming a layer of transcriptome complexity	Homo sapiens

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Release 2023.1 (January 2023)