BRENDA - Enzyme Database
show all sequences of 2.1.1.308

Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster

Woodyer, R.D.; Shao, Z.; Thomas, P.M.; Kelleher, N.L.; Blodgett, J.A.; Metcalf, W.W.; van der Donk, W.A.; Zhao, H.; Chem. Biol. 13, 1171-1182 (2006)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
cloning and characterization of a complete fosfomycin biosynthetic cluster from Streptomyces fradiae and heterologous production of fosfomycin in Streptomyces lividans
Streptomyces fradiae
Organism
Organism
UniProt
Commentary
Textmining
Streptomyces fradiae
D2SNF5
-
-
Synonyms
Synonyms
Commentary
Organism
fom3
-
Streptomyces fradiae
Cloned(Commentary) (protein specific)
Commentary
Organism
cloning and characterization of a complete fosfomycin biosynthetic cluster from Streptomyces fradiae and heterologous production of fosfomycin in Streptomyces lividans
Streptomyces fradiae
Other publictions for EC 2.1.1.308
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
729108
Allen
Initial characterization of Fo ...
Streptomyces wedmorensis
Arch. Biochem. Biophys.
543
67-73
2014
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1
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5
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1
1
1
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1
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1
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2
1
1
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1
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1
1
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5
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1
1
1
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1
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2
1
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1
1
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703345
Booker
Anaerobic functionalization of ...
Streptomyces fradiae
Curr. Opin. Chem. Biol.
13
58-73
2009
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703183
Woodyer
New insight into the mechanism ...
Streptomyces fradiae
Chem. Commun. (Camb. )
4
359-361
2007
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703172
Woodyer
Heterologous production of fos ...
Streptomyces fradiae
Chem. Biol.
13
1171-1182
2006
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1
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1
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705861
Seto
Bioactive natural products wit ...
Streptomyces fradiae, Streptomyces wedmorensis
Nat. Prod. Rep.
16
589-596
1999
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1
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705742
Hidaka
Cloning and nucleotide sequenc ...
Streptomyces wedmorensis, Streptomyces wedmorensis 144-91
Mol. Gen. Genet.
249
274-280
1995
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704215
Kuzuyama
Studies on the biosynthesis of ...
Streptomyces wedmorensis
J. Antibiot.
45
1812-1814
1992
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704807
Hammerschmidt
-
Biosynthesis of natural produc ...
Streptomyces fradiae
J. Chem. Soc. Perkin Trans.
1
1993-1996
1991
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705300
Hammerschmidt
-
Biosynthesis of natural produc ...
Streptomyces fradiae
J. Org. Chem.
56
2364-2370
1991
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