Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PCMB | - |
Bos taurus | |
PCMB | 0.01 mM, complete inhibition | Macaca mulatta | |
PCMB | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.05 | - |
normetanephrine | - |
Macaca mulatta |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Cavia porcellus | - |
- |
- |
Felis catus | - |
- |
- |
Macaca mulatta | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Macaca mulatta |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Rattus norvegicus | - |
adrenal gland | - |
Bos taurus | - |
adrenal gland | - |
Oryctolagus cuniculus | - |
adrenal gland | adrenal medulla has considerably more activity than the cortex | Macaca mulatta | - |
adrenal medulla | - |
Bos taurus | - |
adrenal medulla | - |
Macaca mulatta | - |
heart | - |
Rattus norvegicus | - |
heart | weak activity | Oryctolagus cuniculus | - |
heart | weak activity | Macaca mulatta | - |
Storage Stability | Organism |
---|---|
-10°C, stable for at least 1 month | Macaca mulatta |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,4-dichlorophenylethanolamine + S-adenosyl-L-methionine | - |
Oryctolagus cuniculus | N-methyl-3,4-dichlorophenylethanolamine + S-adenosyl-L-homocysteine | - |
? | |
3,4-dichlorophenylethanolamine + S-adenosyl-L-methionine | - |
Macaca mulatta | N-methyl-3,4-dichlorophenylethanolamine + S-adenosyl-L-homocysteine | - |
? | |
3,4-dichlorophenylethylenediamine + S-adenosyl-L-methionine | - |
Macaca mulatta | ? + S-adenosyl-L-homocysteine | - |
? | |
3,4-dihydroxynorephedrine + S-adenosyl-L-methionine | 18% of the activity with normetanephrine | Macaca mulatta | 3,4-dihydroxyephedrine + S-adenosyl-L-homocysteine | - |
? | |
3-chloro-4-hydroxyphenylethanolamine + S-adenosyl-L-methionine | - |
Macaca mulatta | ? + S-adenosyl-L-homocysteine | - |
? | |
4-hydroxynorephedrine + S-adenosyl-L-methionine | 18% of the activity with normetanephrine | Macaca mulatta | 4-hydroxyephedrine + S-adenosyl-L-homocysteine | - |
? | |
D-norepinephrine + S-adenosyl-L-methionine | - |
Oryctolagus cuniculus | epinephrine + S-adenosyl-L-homocysteine | - |
? | |
D-norepinephrine + S-adenosyl-L-methionine | 15% of the activity with normetanephrine | Macaca mulatta | epinephrine + S-adenosyl-L-homocysteine | - |
? | |
DL-m-hydroxyphenylethanolamine + S-adenosyl-L-methionine | 60% of the activity with normetanephrine | Macaca mulatta | neosynephrine + S-adenosyl-L-homocysteine | - |
? | |
DL-neo-synephrine + S-adenosyl-L-methionine | 20% of the activity with normetanephrine | Macaca mulatta | 3-hydroxy-alpha-[(dimethylamine)methyl]benzenemethanol + S-adenosyl-L-homocysteine | - |
? | |
DL-octopamine + S-adenosyl-L-methionine | 18% of the activity with normetanephrine | Macaca mulatta | ? + S-adenosyl-L-homocysteine | - |
? | |
L-norephedrine + S-adenosyl-L-methionine | 14% of the activity with normetanephrine | Macaca mulatta | ephedrine + S-adenosyl-L-homocysteine | - |
? | |
L-norepinephrine + S-adenosyl-L-methionine | - |
Oryctolagus cuniculus | epinephrine + S-adenosyl-L-homocysteine | - |
? | |
L-norepinephrine + S-adenosyl-L-methionine | 21% of the activity with normetanephrine | Macaca mulatta | epinephrine + S-adenosyl-L-homocysteine | - |
? | |
normetanephrine + S-adenosyl-L-methionine | - |
Bos taurus | metanephrine + S-adenosyl-L-homocysteine | - |
? | |
normetanephrine + S-adenosyl-L-methionine | - |
Macaca mulatta | metanephrine + S-adenosyl-L-homocysteine | - |
? | |
phenylethanolamine + S-adenosyl-L-methionine | - |
Bos taurus | N-methylphenylethanolamine + S-adenosyl-L-homocysteine | - |
? | |
phenylethanolamine + S-adenosyl-L-methionine | - |
Oryctolagus cuniculus | N-methylphenylethanolamine + S-adenosyl-L-homocysteine | - |
? | |
phenylethanolamine + S-adenosyl-L-methionine | 72% of the activity with normetanephrine | Macaca mulatta | N-methylphenylethanolamine + S-adenosyl-L-homocysteine | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8.2 | phosphate buffer | Macaca mulatta |
8 | 9 | Tris buffer | Macaca mulatta |