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Literature summary for 2.1.1.20 extracted from

  • Liu, S.; Li, Y.; Chen, Y.; Chiang, E.; Li, A.F.; Lee, Y.; Tsai, T.; Hsiao, M.; Huang, S.; Chen, Y.A.
    Glycine N-methyltransferase -/- mice develop chronic hepatitis and glycogen storage disease in the liver (2008), Hepatology, 47, 768-769.
No PubMed abstract available
Search for more literature for 2.1.1.20

Protein Variants

Protein Variants Comment Organism
additional information construction of -/- and +/- knockout mutants, Gnmt -/- mice show hepatomegaly, hypermethioninemia, and significantly higher levels of serum alanine aminotransferase and hepatic S-adenosylmethionine, down regulation of S-adenosylhomocysteine hydrolase and formiminotransferase cyclodeaminase, abnormally high glycogen accumulation in liver, hypoglycemia, increased serum cholesterol, and significantly lower numbers of white blood cells, neutrophils, and monocytes, some genes of gluconeogenesis enzyme significantly down regulated in Gnmt -/- mice Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus major folate binding protein, involved in the regulation of the expression of S-adenosylhomocysteine hydrolase and formiminotransferase cyclodeaminase, binds benzo(a)pyrene and prevents DNA-adduct formation ?
-
 ?
S-adenosyl-L-methionine + glycine Mus musculus key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine, affects genetic stability by regulating DNA methylation and interacting with environmental carcinogens S-adenosyl-L-homocysteine + N-methylglycine N-methylglycine = sarcosine ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 construction of -/- and +/- knockout mutants
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte higher expression level in female than in male mice Mus musculus
-
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-
additional information not detected in brain Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information major folate binding protein, involved in the regulation of the expression of S-adenosylhomocysteine hydrolase and formiminotransferase cyclodeaminase, binds benzo(a)pyrene and prevents DNA-adduct formation Mus musculus ?
-
 ?
S-adenosyl-L-methionine + glycine key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine, affects genetic stability by regulating DNA methylation and interacting with environmental carcinogens Mus musculus S-adenosyl-L-homocysteine + N-methylglycine N-methylglycine = sarcosine ?

Synonyms

Synonyms Comment Organism
4S polycyclic aromatic hydrocarbon binding protein
-
 Mus musculus
GNMT
-
 Mus musculus
Gnmt gene product
-
 Mus musculus