Cloned (Comment) | Organism |
---|---|
- |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + pseudouridine1915 in 23S rRNA | Escherichia coli | - |
S-adenosyl-L-homocysteine + N3-methylpseudouridine1915 in 23S rRNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0A8I8 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
S-adenosyl-L-methionine + pseudouridine1915 in 23S rRNA = S-adenosyl-L-homocysteine + N3-methylpseudouridine1915 in 23S rRNA | mechanism: the enzyme docks into the ribosomal A site without encroaching into the P site. YbeA makes extensive interface contacts with both the 30S and 50S subunits to align its active site cofactor adjacent to nucleotide C1915 | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + pseudouridine1915 in 23S rRNA | - |
Escherichia coli | S-adenosyl-L-homocysteine + N3-methylpseudouridine1915 in 23S rRNA | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
m3Psi methyltransferase | - |
Escherichia coli |
RlmH | - |
Escherichia coli |
rRNA large subunit methyltransferase H | - |
Escherichia coli |
YbeA | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
malfunction | inactivation of the ybeA gene leads to loss of methylation at nucleotide C1915, loss of ybeA function in Escherichia coli causes a slight slowing of the growth rate | Escherichia coli |
physiological function | methylation by YbeA possibly functions as a stamp of approval signifying that the 50S subunit has engaged in translational initiation | Escherichia coli |