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Literature summary for 2.1.1.103 extracted from

  • Chen, W.; Taylor, M.C.; Barrow, R.A.; Croyal, M.; Masle, J.
    Loss of phosphoethanolamine N-methyltransferases abolishes phosphatidylcholine synthesis and is lethal (2019), Plant Physiol., 179, 124-142 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.103

Protein Variants

Protein Variants Comment Organism
E8A mutation of NMT2 isoform 2, loss of activity Arabidopsis thaliana
K13A mutation of NMT2 isoform 2, loss of activity Arabidopsis thaliana
R9A mutation of NMT2 isoform 2, loss of activity Arabidopsis thaliana
W16A mutation of NMT2 isoform 2, loss of activity Arabidopsis thaliana
Y15A mutation of NMT2 isoform 2, loss of activity Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q944H0 isoform NMT2
-

Source Tissue

Source Tissue Comment Organism Textmining
flower expression of NMT2 isoform 2 Arabidopsis thaliana
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flower bud expression of NMT2 isoform 2 Arabidopsis thaliana
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leaf rosette or cauline leaf, expression of NMT2 isoform 1 Arabidopsis thaliana
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seedling young seedling, expression of NMT2 isoform 1 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ethanolamine phosphate + S-adenosyl-L-methionine
-
 Arabidopsis thaliana N-methylethanolamine phosphate + S-adenosyl-L-homocysteine
-
 ?
additional information the two NMT2 isoforms have the in vitro capacity to catalyze the triple methylation of phosphoethanolamine to produce choline phosphate, but with different efficiencies Arabidopsis thaliana ?
-
-
N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine
-
 Arabidopsis thaliana choline phosphate + S-adenosyl-L-homocysteine
-
 ?
N-methylethanolamine phosphate + S-adenosyl-L-methionine
-
 Arabidopsis thaliana N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine
-
 ?

Synonyms

Synonyms Comment Organism
NMT2
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function the isoforms NMT1/NMT3 double knock-out mutant is viable. This is enabled by residual phosphoethanolamine N-methyltransferase activity through isoform NMT2. The triple NMT1/NMT2/NMT3 knock-out mutant cannot synthesize phosphatidylcholine from phosphoethanolamine and is lethal. Through alternative use of its promoter, NMT2 encodes two phosphoethanolamine N-methyltransferase variants, which greatly differ in their ability to perform the initial phosphobase methylation of phosphoethanolamine Arabidopsis thaliana