Cloned (Comment) | Organism |
---|---|
expression in Sf9 cells | Trypanosoma brucei |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
n-octyl beta-glucoside | 0.2%, 55-75% inhibition | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00017 | - |
N-acetyl-S-(E,E)-farnesyl-L-cysteine | recombinant enzyme | Trypanosoma brucei | |
0.0014 | - |
N-acetyl-S-(E,E)-farnesyl-L-cysteine | native enzyme | Trypanosoma brucei | |
0.0023 | - |
N-acetyl-S-geranylgeranyl-L-cysteine | recombinant enzyme | Trypanosoma brucei | |
0.004 | - |
N-acetyl-S-geranylgeranyl-L-cysteine | native enzyme | Trypanosoma brucei | |
0.0115 | - |
N-acetyl-S-(E,E)-farnesyl-L-cysteine | native enzyme | Mus musculus | |
0.0116 | - |
N-acetyl-S-geranylgeranyl-L-cysteine | native enzyme | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
28301 | - |
x * 28301, deduced from nucleotide sequence | Trypanosoma brucei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Trypanosoma brucei | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteine | - |
Mus musculus | S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteine methyl ester | - |
? | |
S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteine | - |
Trypanosoma brucei | S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteine methyl ester | - |
? | |
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine | - |
Mus musculus | S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester | - |
? | |
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine | - |
Trypanosoma brucei | S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester | - |
? | |
S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-L-cysteine | - |
Mus musculus | S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester | - |
? | |
S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-L-cysteine | recombinant enzyme: 50fold higher activity than with N-acetyl-S-geranylgeranyl-L-cysteine, native enzyme: 40fold higher activity than with N-acetyl-S-geranylgeranyl-L-cysteine | Trypanosoma brucei | S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 28301, deduced from nucleotide sequence | Trypanosoma brucei |