Literature summary for 1.8.4.11 extracted from

Guan, X.L.; Wu, P.F.; Wang, S.; Zhang, J.J.; Shen, Z.C.; Luo, H.; Chen, H.; Long, L.H.; Chen, J.G.; Wang, F.
Dimethyl sulfide protects against oxidative stress and extends lifespan via a methionine sulfoxide reductase A-dependent catalytic mechanism (2017), Aging Cell, 16, 226-236 .

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Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	O02089	-	-
Drosophila melanogaster	-	-	-
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dimethylsulfide + thioredoxin disulfide + H2O	-	Drosophila melanogaster	dimethylsulfoxide + thioredoxin	-	?
dimethylsulfide + thioredoxin disulfide + H2O	-	Rattus norvegicus	dimethylsulfoxide + thioredoxin	-	?
dimethylsulfide + thioredoxin disulfide + H2O	-	Caenorhabditis elegans	dimethylsulfoxide + thioredoxin	-	?

Synonyms

Synonyms	Comment	Organism
MsrA	-	Drosophila melanogaster
MsrA	-	Rattus norvegicus
MsrA	-	Caenorhabditis elegans

General Information

General Information	Comment	Organism
physiological function	supplement of dimethylsulfide leads to cytoprotection and extends longevity. MsrA knockdown abolishes the cytoprotective effect and the longevity benefits of dimethylsulfide	Drosophila melanogaster
physiological function	supplement of dimethylsulfide leads to cytoprotection and extends longevity. MsrA knockdown abolishes the cytoprotective effect and the longevity benefits of dimethylsulfide	Caenorhabditis elegans

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Release 2023.1 (January 2023)