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Literature summary for 1.8.4.11 extracted from
- Peptide methionine sulfoxide reductase (MsrA) is not a major virulence determinant for the oral pathogen Actinobacillus actinomycetemcomitans (2002), Microbiology, 148, 3695-3703.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene msrA, DNA and amino acid sequence determination and analysis | Aggregatibacter actinomycetemcomitans |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | msrA gene inactivation by chromosomal insertion via allele replacement mutagenesis does not lead to increased sensitivity against oxidative stress but to complete loss of enzymatic activity with synthetic substrates | Aggregatibacter actinomycetemcomitans |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | subcellular localization analysis, overview | Aggregatibacter actinomycetemcomitans | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Aggregatibacter actinomycetemcomitans | the enzyme is not a major virulence determinant in the oral pathogen, MsrA is required for protein repair and protection against oxidative damage as well as for the proper expression or maintenance of functional adhesins | ? | - |
? |  |
| peptide-L-methionine-(S)-S-oxide + thioredoxin | Aggregatibacter actinomycetemcomitans | stereospecific reduction | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aggregatibacter actinomycetemcomitans | Q9AL99 | strains VT1169 and VT1530 derived from the clinical strain SUNY 465 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dabsyl-L-methionine-(S)-S-oxide + DTT | stereospecific reduction | Aggregatibacter actinomycetemcomitans | dabsyl-L-methionine + DTT disulfide + H2O | - |
? | |
| additional information | the enzyme is not a major virulence determinant in the oral pathogen, MsrA is required for protein repair and protection against oxidative damage as well as for the proper expression or maintenance of functional adhesins | Aggregatibacter actinomycetemcomitans | ? | - |
? | |
| peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Aggregatibacter actinomycetemcomitans | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MsrA | - |
Aggregatibacter actinomycetemcomitans |
| peptide methionine sulfoxide reductase | - |
Aggregatibacter actinomycetemcomitans |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Aggregatibacter actinomycetemcomitans |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Aggregatibacter actinomycetemcomitans |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | - |
Aggregatibacter actinomycetemcomitans | |
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