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Literature summary for 1.8.4.11 extracted from

  • Moskovitz, J.
    Roles of methionine suldfoxide reductases in antioxidant defense, protein regulation and survival (2005), Curr. Pharm. Des., 11, 1451-1457.
    View publication on PubMed
Search for more literature for 1.8.4.11

Activating Compound

Activating Compound Comment Organism Structure
additional information the calcium phospholipid-binding protein, CPBP, is an analogue of the elongation factor 1-gamma and regulates MsrA expression by binding to the MsrA promoter, starvation induces MsrA expression, also diamide treatment and gamma-irradiation induce the enzyme Saccharomyces cerevisiae
additional information starvation induces the expression of MsrA Escherichia coli
additional information the antibiotic oxacillin induces MsrA expression Staphylococcus aureus
additional information chronic dietary intake of soybean protein induces the expression of MsrA Sus scrofa

Protein Variants

Protein Variants Comment Organism
additional information yeast cells lacking MsrA show increased sensitivity to oxidative damage, a shortened lifespan under hyperoxic conditions, and methionine-(S)-S-oxide accumulation Saccharomyces cerevisiae
additional information msrA gene disruption leads to a shortened life span both under normoxic and hyperoxic conditions, MsrA null mutant mice shows greater sensitivity to hyperoxic conditions compared to wild-type mice, construction of MsrA overexpressing strains, phenotypes, overview Mus musculus
additional information bacterial cells lacking MsrA show increased sensitivity to oxidative damage, a shortened lifespan under hyperoxic conditions, and methionine-(R)-S-oxide accumulation Escherichia coli
additional information bacterial cells lacking MsrA show increased sensitivity to oxidative damage, a shortened lifespan under hyperoxic conditions, and methionine-(R)-S-oxide accumulation Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-methionine-(S)-S-oxide + thioredoxin Saccharomyces cerevisiae
-
 L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin Homo sapiens substrates are HIV-2, which is inactivated by oxidation of its methionine residues M76 and M95, the potassium channel of the brain, the inhibitor IkappaB-alpha, or calmodulin, overview L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin Mus musculus
-
 L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin Escherichia coli
-
 L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin Staphylococcus aureus
-
 L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin Arabidopsis thaliana
-
 L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin Sus scrofa
-
 L-methionine + thioredoxin disulfide + H2O
-
 ?
additional information Saccharomyces cerevisiae roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrA protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway ?
-
 ?
additional information Homo sapiens roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrA protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview ?
-
 ?
additional information Mus musculus roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrA protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview ?
-
 ?
additional information Escherichia coli roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrA protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview ?
-
 ?
additional information Staphylococcus aureus roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrA protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview ?
-
 ?
additional information Arabidopsis thaliana roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrA protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview ?
-
 ?
additional information Sus scrofa roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrA protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview ?
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin Saccharomyces cerevisiae
-
 peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin Homo sapiens
-
 peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin Mus musculus
-
 peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin Escherichia coli
-
 peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin Staphylococcus aureus
-
 peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin Arabidopsis thaliana substrate in vivo is e.g. the small heat shock protein Hsp-21 which loses its chaperone-like activity upon methionine oxidation peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin Sus scrofa
-
 peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Saccharomyces cerevisiae
-
-
-
Staphylococcus aureus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine-(S)-S-oxide + thioredoxin
-
 Saccharomyces cerevisiae L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin substrates are HIV-2, which is inactivated by oxidation of its methionine residues M76 and M95, the potassium channel of the brain, the inhibitor IkappaB-alpha, or calmodulin, overview Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin
-
 Mus musculus L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin
-
 Escherichia coli L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin
-
 Staphylococcus aureus L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin
-
 Arabidopsis thaliana L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin
-
 Sus scrofa L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Saccharomyces cerevisiae L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Mus musculus L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Escherichia coli L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Staphylococcus aureus L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Arabidopsis thaliana L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Sus scrofa L-methionine + thioredoxin disulfide + H2O
-
 ?
additional information roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrA protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway Saccharomyces cerevisiae ?
-
 ?
additional information roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrA protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview Homo sapiens ?
-
 ?
additional information roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrA protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview Mus musculus ?
-
 ?
additional information roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrA protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview Escherichia coli ?
-
 ?
additional information roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrA protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview Staphylococcus aureus ?
-
 ?
additional information roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrA protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview Arabidopsis thaliana ?
-
 ?
additional information roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrA protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview Sus scrofa ?
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin
-
 Saccharomyces cerevisiae peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin
-
 Homo sapiens peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin
-
 Mus musculus peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin
-
 Escherichia coli peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin
-
 Staphylococcus aureus peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin substrate in vivo is e.g. the small heat shock protein Hsp-21 which loses its chaperone-like activity upon methionine oxidation Arabidopsis thaliana peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin
-
 Sus scrofa peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Arabidopsis thaliana peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase A
-
 Saccharomyces cerevisiae
methionine sulfoxide reductase A
-
 Homo sapiens
methionine sulfoxide reductase A
-
 Mus musculus
methionine sulfoxide reductase A
-
 Escherichia coli
methionine sulfoxide reductase A
-
 Staphylococcus aureus
methionine sulfoxide reductase A
-
 Arabidopsis thaliana
methionine sulfoxide reductase A
-
 Sus scrofa
additional information the enzyme belongs to the Msr family of enzymes Saccharomyces cerevisiae
additional information the enzyme belongs to the Msr family of enzymes Homo sapiens
additional information the enzyme belongs to the Msr family of enzymes Mus musculus
additional information the enzyme belongs to the Msr family of enzymes Escherichia coli
additional information the enzyme belongs to the Msr family of enzymes Staphylococcus aureus
additional information the enzyme belongs to the Msr family of enzymes Arabidopsis thaliana
additional information the enzyme belongs to the Msr family of enzymes Sus scrofa
MsrA
-
 Saccharomyces cerevisiae
MsrA
-
 Homo sapiens
MsrA
-
 Mus musculus
MsrA
-
 Escherichia coli
MsrA
-
 Staphylococcus aureus
MsrA
-
 Arabidopsis thaliana
MsrA
-
 Sus scrofa

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
 Saccharomyces cerevisiae
thioredoxin
-
 Homo sapiens
thioredoxin
-
 Mus musculus
thioredoxin
-
 Escherichia coli
thioredoxin
-
 Staphylococcus aureus
thioredoxin
-
 Arabidopsis thaliana
thioredoxin
-
 Sus scrofa