Inhibitors | Comment | Organism | Structure |
---|---|---|---|
auranofin | protects cerebellar granular neurons from the action of different doses of tetanus neurotoxin, about 1 microM auranofinF confers a full protection against tetnus neurotoxin intoxication. Auranofin protects cerebellar granular neurons from the cleavage of VAMP-2 induced by botulinum neurotoxi B and the cleavage of syntaxin 1A induced by botulinum neurotoxin C | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | cerebellar granule neuron | Rattus norvegicus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | the thioredoxin system plays a major role in releasing the L chain of tetanus neurotoxin and botulinum neurotoxins after their translocation across the membrane of the endocytic vesicle | Rattus norvegicus |