Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1,3,5-triaza-7-phosphaadamantane)Au(saccharine) | - |
Leishmania infantum | |
Au(2-(2'-pyridyl)benzimidazole)Cl2 | - |
Leishmania infantum | |
Au-(N-(1-hydroxy-3-methylbutan-2-yl)pyridine-2-carboxamide)Cl | - |
Leishmania infantum | |
AuCl3 | - |
Leishmania infantum | |
auranofin | - |
Leishmania infantum | |
K[Au(saccharine)2] | - |
Leishmania infantum | |
K[Au(saccharine)4] | - |
Leishmania infantum | |
[(2,2'-bipyridine)Au(OH)2][PF6] | - |
Leishmania infantum | |
[Au((S)-4-Bn-2-(pyridin-2-yl)-4,5-dihydro-oxazole)Cl2][PF6] | - |
Leishmania infantum | |
[Au((S)-4-iPr-2-(pyridin-2-yl)-4,5-dihydro-oxazole)Cl2][PF6] | - |
Leishmania infantum | |
[Au2(bipy)2(m-O)2](PF6)2 | - |
Leishmania infantum | |
[Cl2AuIII(2-(2'-pyridyl)benzimidazole)AuI(PPh3)](PF6) | - |
Leishmania infantum |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
54680 | - |
2 * 54680, calculated from amino acid sequence | Leishmania infantum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH + H+ | Leishmania infantum | - |
trypanothione + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania infantum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH + H+ | - |
Leishmania infantum | trypanothione + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 54680, calculated from amino acid sequence | Leishmania infantum |
Synonyms | Comment | Organism |
---|---|---|
trypanothione reductase | - |
Leishmania infantum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Leishmania infantum | |
NADPH | dependent on | Leishmania infantum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000022 | - |
[Cl2AuIII(2-(2'-pyridyl)benzimidazole)AuI(PPh3)](PF6) | at pH 7.5 and 25°C | Leishmania infantum | |
0.00004 | - |
[(2,2'-bipyridine)Au(OH)2][PF6] | at pH 7.5 and 25°C | Leishmania infantum | |
0.00005 | - |
(1,3,5-triaza-7-phosphaadamantane)Au(saccharine) | at pH 7.5 and 25°C | Leishmania infantum | |
0.000068 | - |
[Au2(bipy)2(m-O)2](PF6)2 | at pH 7.5 and 25°C | Leishmania infantum | |
0.000075 | - |
[Au((S)-4-iPr-2-(pyridin-2-yl)-4,5-dihydro-oxazole)Cl2][PF6] | at pH 7.5 and 25°C | Leishmania infantum | |
0.00009 | - |
Au(2-(2'-pyridyl)benzimidazole)Cl2 | at pH 7.5 and 25°C | Leishmania infantum | |
0.00014 | - |
K[Au(saccharine)2] | at pH 7.5 and 25°C | Leishmania infantum | |
0.000155 | - |
auranofin | at pH 7.5 and 25°C | Leishmania infantum | |
0.00016 | - |
AuCl3 | at pH 7.5 and 25°C | Leishmania infantum | |
0.000185 | - |
[Au((S)-4-Bn-2-(pyridin-2-yl)-4,5-dihydro-oxazole)Cl2][PF6] | at pH 7.5 and 25°C | Leishmania infantum | |
0.0002 | - |
K[Au(saccharine)4] | at pH 7.5 and 25°C | Leishmania infantum | |
0.025 | - |
Au-(N-(1-hydroxy-3-methylbutan-2-yl)pyridine-2-carboxamide)Cl | at pH 7.5 and 25°C | Leishmania infantum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0005 | - |
at pH 7.5 and 25°C | Leishmania infantum | auranofin | |
0.0006 | - |
at pH 7.5 and 25°C | Leishmania infantum | [Cl2AuIII(2-(2'-pyridyl)benzimidazole)AuI(PPh3)](PF6) | |
0.0014 | - |
at pH 7.5 and 25°C | Leishmania infantum | [Au((S)-4-iPr-2-(pyridin-2-yl)-4,5-dihydro-oxazole)Cl2][PF6] | |
0.00505 | - |
at pH 7.5 and 25°C | Leishmania infantum | [Au((S)-4-Bn-2-(pyridin-2-yl)-4,5-dihydro-oxazole)Cl2][PF6] | |
0.0061 | - |
at pH 7.5 and 25°C | Leishmania infantum | Au-(N-(1-hydroxy-3-methylbutan-2-yl)pyridine-2-carboxamide)Cl | |
0.0066 | - |
at pH 7.5 and 25°C | Leishmania infantum | Au(2-(2'-pyridyl)benzimidazole)Cl2 | |
0.0085 | - |
at pH 7.5 and 25°C | Leishmania infantum | (1,3,5-triaza-7-phosphaadamantane)Au(saccharine) | |
0.0088 | - |
at pH 7.5 and 25°C | Leishmania infantum | [(2,2'-bipyridine)Au(OH)2][PF6] | |
0.0101 | - |
at pH 7.5 and 25°C | Leishmania infantum | AuCl3 | |
0.0149 | - |
at pH 7.5 and 25°C | Leishmania infantum | K[Au(saccharine)4] | |
0.0228 | - |
at pH 7.5 and 25°C | Leishmania infantum | [Au2(bipy)2(m-O)2](PF6)2 | |
0.0527 | - |
at pH 7.5 and 25°C | Leishmania infantum | K[Au(saccharine)2] |