Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-4-chlorophenyl phenyl sulfide | weak inhibitor | Trypanosoma cruzi | |
3',4'-dichlorobenzyl-[5-chloro-2-(phenylsulfanylphenylamino)-propyl]-dimethylammonium chloride | - |
Trypanosoma cruzi | |
3,3'-[butane-1,4-diylbis[(3-aminopropyl)imino]]bis(N-[5-chloro-2-[(4-methoxyphenyl)sulfanyl]phenyl]propanamide) | IC50: 0.0003 mM | Trypanosoma cruzi | |
3,4-dichloro-N-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-N,N-dimethylanilinium | - |
Trypanosoma cruzi | |
3,4-dichloro-N-[3-([2-[(4-chlorophenyl)sulfanyl]phenyl]amino)propyl]-N,N-dimethylanilinium | - |
Trypanosoma cruzi | |
3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine | - |
Trypanosoma cruzi | |
4-(benzyloxy)-N-[3-([2-[(4-chlorophenyl)sulfanyl]phenyl]amino)propyl]-N,N-dimethylanilinium | - |
Trypanosoma cruzi | |
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-(phenylsulfanyl)aniline | - |
Trypanosoma cruzi | |
amitryptyline | - |
Trypanosoma cruzi | |
chlorpromazine | - |
Trypanosoma cruzi | |
N'-[5-chloro-2-(phenylsulfanyl)phenyl]-N,N-dimethylpropane-1,3-diamine | - |
Trypanosoma cruzi | |
N-(3-chlorophenyl)-N',N'-dimethyl-N-phenylpropane-1,3-diamine | - |
Trypanosoma cruzi | |
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-phenylacetamide | IC50: 0.0368 mM | Trypanosoma cruzi | |
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-4-nitrobenzamide | IC50: 0.0445 mM | Trypanosoma cruzi | |
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]benzamide | IC50: 0.0496 mM | Trypanosoma cruzi | |
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]butanamide | IC50: 0.0305 mM | Trypanosoma cruzi | |
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]propanamide | IC50: 0.0316 mM | Trypanosoma cruzi | |
N-[3-([2-[(4-chlorophenyl)sulfanyl]phenyl]amino)propyl]-4-(diphenylmethoxy)-N,N-dimethylanilinium | - |
Trypanosoma cruzi | |
N-[3-([2-[(4-chlorophenyl)sulfanyl]phenyl]amino)propyl]-N,N-dimethylanilinium | - |
Trypanosoma cruzi | |
promazine | - |
Trypanosoma cruzi | |
Trifluperazine | - |
Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TR | - |
Trypanosoma cruzi |
trypanothione reductase | - |
Trypanosoma cruzi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Trypanosoma cruzi |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00044 | - |
3,4-dichloro-N-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-N,N-dimethylanilinium | 0.0008 mM, at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.00169 | - |
3,4-dichloro-N-[3-([2-[(4-chlorophenyl)sulfanyl]phenyl]amino)propyl]-N,N-dimethylanilinium | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.0017 | - |
3',4'-dichlorobenzyl-[5-chloro-2-(phenylsulfanylphenylamino)-propyl]-dimethylammonium chloride | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.0053 | - |
N-[3-([2-[(4-chlorophenyl)sulfanyl]phenyl]amino)propyl]-4-(diphenylmethoxy)-N,N-dimethylanilinium | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.0065 | - |
3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.0066 | - |
4-(benzyloxy)-N-[3-([2-[(4-chlorophenyl)sulfanyl]phenyl]amino)propyl]-N,N-dimethylanilinium | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.0108 | - |
chlorpromazine | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.0113 | - |
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]butanamide | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.0142 | - |
N-[3-([2-[(4-chlorophenyl)sulfanyl]phenyl]amino)propyl]-N,N-dimethylanilinium | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.02 | - |
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]propanamide | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.023 | - |
Trifluperazine | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.0245 | - |
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]benzamide | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.0246 | - |
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-phenylacetamide | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.027 | - |
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-(phenylsulfanyl)aniline | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.0428 | - |
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-4-nitrobenzamide | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.066 | - |
N'-[5-chloro-2-(phenylsulfanyl)phenyl]-N,N-dimethylpropane-1,3-diamine | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.0936 | - |
amitryptyline | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi | |
0.15 | - |
2-amino-4-chlorophenyl phenyl sulfide | at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH | Trypanosoma cruzi |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0003 | - |
IC50: 0.0003 mM | Trypanosoma cruzi | 3,3'-[butane-1,4-diylbis[(3-aminopropyl)imino]]bis(N-[5-chloro-2-[(4-methoxyphenyl)sulfanyl]phenyl]propanamide) | |
0.0305 | - |
IC50: 0.0305 mM | Trypanosoma cruzi | N-[2-[(4-chlorophenyl)sulfanyl]phenyl]butanamide | |
0.0316 | - |
IC50: 0.0316 mM | Trypanosoma cruzi | N-[2-[(4-chlorophenyl)sulfanyl]phenyl]propanamide | |
0.0368 | - |
IC50: 0.0368 mM | Trypanosoma cruzi | N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-phenylacetamide | |
0.0445 | - |
IC50: 0.0445 mM | Trypanosoma cruzi | N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-4-nitrobenzamide | |
0.0496 | - |
IC50: 0.0496 mM | Trypanosoma cruzi | N-[2-[(4-chlorophenyl)sulfanyl]phenyl]benzamide |