Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme activity is potently inhibited by thyroid hormones | Canis lupus familiaris | |
additional information | the enzyme activity is potently inhibited by thyroid hormones | Homo sapiens | |
additional information | the enzyme activity is potently inhibited by thyroid hormones | Mus musculus | |
additional information | the enzyme activity is potently inhibited by thyroid hormones | Ovis aries | |
additional information | the enzyme activity is potently inhibited by thyroid hormones | Rattus norvegicus | |
additional information | the enzyme activity is potently inhibited by thyroid hormones | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Canis lupus familiaris | 5829 | - |
cytosol | - |
Sus scrofa | 5829 | - |
cytosol | - |
Ovis aries | 5829 | - |
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DELTA1-piperideine 2-carboxylate + NADH + H+ | Sus scrofa | - |
L-pipecolate + NAD+ | - |
? | |
DELTA1-piperideine 2-carboxylate + NADH + H+ | Ovis aries | - |
L-pipecolate + NAD+ | - |
? | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | Canis lupus familiaris | - |
L-pipecolate + NADP+ | - |
r | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | Sus scrofa | - |
L-pipecolate + NADP+ | - |
? | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | Ovis aries | - |
L-pipecolate + NADP+ | - |
? | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | Mus musculus | - |
L-pipecolate + NADP+ | - |
r | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | Homo sapiens | - |
L-pipecolate + NADP+ | - |
r | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | Rattus norvegicus | - |
L-pipecolate + NADP+ | - |
r | |
DELTA1-pyrrolidine 2-carboxylate + NADH + H+ | Sus scrofa | - |
L-pipecolate + NAD+ | - |
? | |
DELTA1-pyrrolidine 2-carboxylate + NADH + H+ | Ovis aries | - |
L-pipecolate + NAD+ | - |
? | |
DELTA1-pyrrolidine 2-carboxylate + NADPH + H+ | Sus scrofa | - |
L-pipecolate + NADP+ | - |
? | |
DELTA1-pyrrolidine 2-carboxylate + NADPH + H+ | Ovis aries | - |
L-pipecolate + NADP+ | - |
? | |
additional information | Mus musculus | the same enzyme catalyzes the reduction of both DELTA1-piperideine-2-carboxylate and DELTA1-pyrrolidine-2-carboxylate, but is unable to catalyze the reduction of DELTA1-pyrroline-5-carboxylate and DELTA1-piperideine-6-carboxylate, which may be regarded as double bond positional isomers of DELTA1-piperideine-2-carboxylate and DELTA1-pyrrolidine-2-carboxylate, respectively | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Homo sapiens | Q14894 | - |
- |
Mus musculus | O54983 | - |
- |
Ovis aries | W5PYW4 | - |
- |
Rattus norvegicus | Q9QYU4 | - |
- |
Sus scrofa | F1RPC8 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Canis lupus familiaris | - |
astrocyte | - |
Sus scrofa | - |
astrocyte | - |
Ovis aries | - |
astrocyte | - |
Mus musculus | - |
astrocyte | - |
Homo sapiens | - |
astrocyte | - |
Rattus norvegicus | - |
brain | - |
Canis lupus familiaris | - |
brain | - |
Sus scrofa | - |
brain | - |
Ovis aries | - |
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
kidney | - |
Sus scrofa | - |
liver | - |
Rattus norvegicus | - |
satellite cell | - |
Canis lupus familiaris | - |
satellite cell | - |
Sus scrofa | - |
satellite cell | - |
Ovis aries | - |
satellite cell | - |
Mus musculus | - |
satellite cell | - |
Homo sapiens | - |
satellite cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DELTA1-piperideine 2-carboxylate + NADH + H+ | - |
Sus scrofa | L-pipecolate + NAD+ | - |
? | |
DELTA1-piperideine 2-carboxylate + NADH + H+ | - |
Ovis aries | L-pipecolate + NAD+ | - |
? | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | - |
Canis lupus familiaris | L-pipecolate + NADP+ | - |
r | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | - |
Sus scrofa | L-pipecolate + NADP+ | - |
? | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | - |
Ovis aries | L-pipecolate + NADP+ | - |
? | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | - |
Mus musculus | L-pipecolate + NADP+ | - |
r | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | - |
Homo sapiens | L-pipecolate + NADP+ | - |
r | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | - |
Rattus norvegicus | L-pipecolate + NADP+ | - |
r | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | the equilibrium position lies far toward formation of the six-membered ring structure L-pipecolate at neutral pH | Canis lupus familiaris | L-pipecolate + NADP+ | - |
r | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | the equilibrium position lies far toward formation of the six-membered ring structure L-pipecolate at neutral pH | Sus scrofa | L-pipecolate + NADP+ | - |
? | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | the equilibrium position lies far toward formation of the six-membered ring structure L-pipecolate at neutral pH | Ovis aries | L-pipecolate + NADP+ | - |
? | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | the equilibrium position lies far toward formation of the six-membered ring structure L-pipecolate at neutral pH | Mus musculus | L-pipecolate + NADP+ | - |
r | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | the equilibrium position lies far toward formation of the six-membered ring structure L-pipecolate at neutral pH | Homo sapiens | L-pipecolate + NADP+ | - |
r | |
DELTA1-piperideine 2-carboxylate + NADPH + H+ | the equilibrium position lies far toward formation of the six-membered ring structure L-pipecolate at neutral pH | Rattus norvegicus | L-pipecolate + NADP+ | - |
r | |
DELTA1-pyrrolidine 2-carboxylate + NADH + H+ | - |
Sus scrofa | L-pipecolate + NAD+ | - |
? | |
DELTA1-pyrrolidine 2-carboxylate + NADH + H+ | - |
Ovis aries | L-pipecolate + NAD+ | - |
? | |
DELTA1-pyrrolidine 2-carboxylate + NADPH + H+ | - |
Sus scrofa | L-pipecolate + NADP+ | - |
? | |
DELTA1-pyrrolidine 2-carboxylate + NADPH + H+ | - |
Ovis aries | L-pipecolate + NADP+ | - |
? | |
additional information | the same enzyme catalyzes the reduction of both DELTA1-piperideine-2-carboxylate and DELTA1-pyrrolidine-2-carboxylate, but is unable to catalyze the reduction of DELTA1-pyrroline-5-carboxylate and DELTA1-piperideine-6-carboxylate, which may be regarded as double bond positional isomers of DELTA1-piperideine-2-carboxylate and DELTA1-pyrrolidine-2-carboxylate, respectively | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CRYM | - |
Canis lupus familiaris |
CRYM | - |
Sus scrofa |
CRYM | - |
Ovis aries |
CRYM | - |
Mus musculus |
CRYM | - |
Homo sapiens |
CRYM | - |
Rattus norvegicus |
ketimine reductase | - |
Canis lupus familiaris |
ketimine reductase | - |
Sus scrofa |
ketimine reductase | - |
Ovis aries |
ketimine reductase | - |
Mus musculus |
ketimine reductase | - |
Homo sapiens |
ketimine reductase | - |
Rattus norvegicus |
mu-crystallin | - |
Canis lupus familiaris |
mu-crystallin | - |
Sus scrofa |
mu-crystallin | - |
Ovis aries |
mu-crystallin | - |
Mus musculus |
mu-crystallin | - |
Homo sapiens |
mu-crystallin | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Sus scrofa | |
NADH | - |
Ovis aries | |
NADPH | - |
Canis lupus familiaris | |
NADPH | - |
Sus scrofa | |
NADPH | - |
Ovis aries | |
NADPH | - |
Mus musculus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is important in the L-pipecolate pathway, overview. Besides the pipecolate pathway, the enzyme is also involved in L-ornithine/L-glutamate/L-proline metabolism as well as sulfur-containing amino acid metabolism. There are two ways of lysine degradation, although the saccharopine pathway can be detected in the adult mouse brain, the pipecolate pathway greatly predominates in the adult mammalian brain. Pathway regulation, overview | Mus musculus |
metabolism | the enzyme is important in the L-pipecolate pathway, overview. Besides the pipecolate pathway, the enzyme is also involved in L-ornithine/L-glutamate/L-proline metabolism as well as sulfur-containing amino acid metabolism. There are two ways of lysine degradation, the saccharopine pathway and the pipecolate pathway, the latter dominates in the adult mammalian brain. Pathway regulation, overview | Canis lupus familiaris |
metabolism | the enzyme is important in the L-pipecolate pathway, overview. Besides the pipecolate pathway, the enzyme is also involved in L-ornithine/L-glutamate/L-proline metabolism as well as sulfur-containing amino acid metabolism. There are two ways of lysine degradation, the saccharopine pathway and the pipecolate pathway, the latter dominates in the adult mammalian brain. Pathway regulation, overview | Sus scrofa |
metabolism | the enzyme is important in the L-pipecolate pathway, overview. Besides the pipecolate pathway, the enzyme is also involved in L-ornithine/L-glutamate/L-proline metabolism as well as sulfur-containing amino acid metabolism. There are two ways of lysine degradation, the saccharopine pathway and the pipecolate pathway, the latter dominates in the adult mammalian brain. Pathway regulation, overview | Ovis aries |
metabolism | the enzyme is important in the L-pipecolate pathway, overview. Besides the pipecolate pathway, the enzyme is also involved in L-ornithine/L-glutamate/L-proline metabolism as well as sulfur-containing amino acid metabolism. There are two ways of lysine degradation, the saccharopine pathway and the pipecolate pathway, the latter dominates in the adult mammalian brain. Pathway regulation, overview | Homo sapiens |
metabolism | the enzyme is important in the L-pipecolate pathway, overview. Besides the pipecolate pathway, the enzyme is also involved in L-ornithine/L-glutamate/L-proline metabolism as well as sulfur-containing amino acid metabolism. There are two ways of lysine degradation, the saccharopine pathway and the pipecolate pathway, the latter dominates in the adult mammalian brain. Pathway regulation, overview | Rattus norvegicus |
additional information | enzymes that reduce DELTA1-pyrroline-5-carboxylate/DELTA1-piperideine-6-carboxylate (Pyr5C/P6C) are aldimine reductases, whereas enzymes that reduce DELTA1-pyrroline-2-carboxylate/DELTA1-piperideine-2-carboxylate (Pyr2C/P2C) are ketimine reductases | Canis lupus familiaris |
additional information | enzymes that reduce DELTA1-pyrroline-5-carboxylate/DELTA1-piperideine-6-carboxylate (Pyr5C/P6C) are aldimine reductases, whereas enzymes that reduce DELTA1-pyrroline-2-carboxylate/DELTA1-piperideine-2-carboxylate (Pyr2C/P2C) are ketimine reductases | Sus scrofa |
additional information | enzymes that reduce DELTA1-pyrroline-5-carboxylate/DELTA1-piperideine-6-carboxylate (Pyr5C/P6C) are aldimine reductases, whereas enzymes that reduce DELTA1-pyrroline-2-carboxylate/DELTA1-piperideine-2-carboxylate (Pyr2C/P2C) are ketimine reductases | Ovis aries |
additional information | enzymes that reduce DELTA1-pyrroline-5-carboxylate/DELTA1-piperideine-6-carboxylate (Pyr5C/P6C) are aldimine reductases, whereas enzymes that reduce DELTA1-pyrroline-2-carboxylate/DELTA1-piperideine-2-carboxylate (Pyr2C/P2C) are ketimine reductases | Mus musculus |
additional information | enzymes that reduce DELTA1-pyrroline-5-carboxylate/DELTA1-piperideine-6-carboxylate (Pyr5C/P6C) are aldimine reductases, whereas enzymes that reduce DELTA1-pyrroline-2-carboxylate/DELTA1-piperideine-2-carboxylate (Pyr2C/P2C) are ketimine reductases | Homo sapiens |
additional information | enzymes that reduce DELTA1-pyrroline-5-carboxylate/DELTA1-piperideine-6-carboxylate (Pyr5C/P6C) are aldimine reductases, whereas enzymes that reduce DELTA1-pyrroline-2-carboxylate/DELTA1-piperideine-2-carboxylate (Pyr2C/P2C) are ketimine reductases | Rattus norvegicus |
physiological function | CRYM has the ability to strongly bind thyroid hormones in an NADPH-dependent fashion. CRYM is also an enzyme, namely ketimine reductase, which catalyzes the NAD(P)H-dependent reduction of -C=N- (imine) double bonds of a number of cyclic ketimine substrates including sulfur-containing cyclic ketimines, the enzyme has a biological function in its degradative role as a DELTA1-piperideine-2-carboxylate (P2C) reductase in the pipecolate pathway of lysine metabolism. The pipecolate pathway is the main L-lysine degradation pathway in the adult brain. Potent regulation of ketimine reductase activity by thyroid hormones | Canis lupus familiaris |
physiological function | CRYM has the ability to strongly bind thyroid hormones in an NADPH-dependent fashion. CRYM is also an enzyme, namely ketimine reductase, which catalyzes the NAD(P)H-dependent reduction of -C=N- (imine) double bonds of a number of cyclic ketimine substrates including sulfur-containing cyclic ketimines, the enzyme has a biological function in its degradative role as a DELTA1-piperideine-2-carboxylate (P2C) reductase in the pipecolate pathway of lysine metabolism. The pipecolate pathway is the main L-lysine degradation pathway in the adult brain. Potent regulation of ketimine reductase activity by thyroid hormones | Sus scrofa |
physiological function | CRYM has the ability to strongly bind thyroid hormones in an NADPH-dependent fashion. CRYM is also an enzyme, namely ketimine reductase, which catalyzes the NAD(P)H-dependent reduction of -C=N- (imine) double bonds of a number of cyclic ketimine substrates including sulfur-containing cyclic ketimines, the enzyme has a biological function in its degradative role as a DELTA1-piperideine-2-carboxylate (P2C) reductase in the pipecolate pathway of lysine metabolism. The pipecolate pathway is the main L-lysine degradation pathway in the adult brain. Potent regulation of ketimine reductase activity by thyroid hormones | Ovis aries |
physiological function | CRYM has the ability to strongly bind thyroid hormones in an NADPH-dependent fashion. CRYM is also an enzyme, namely ketimine reductase, which catalyzes the NAD(P)H-dependent reduction of -C=N- (imine) double bonds of a number of cyclic ketimine substrates including sulfur-containing cyclic ketimines, the enzyme has a biological function in its degradative role as a DELTA1-piperideine-2-carboxylate (P2C) reductase in the pipecolate pathway of lysine metabolism. The pipecolate pathway is the main L-lysine degradation pathway in the adult brain. Potent regulation of ketimine reductase activity by thyroid hormones | Mus musculus |
physiological function | CRYM has the ability to strongly bind thyroid hormones in an NADPH-dependent fashion. CRYM is also an enzyme, namely ketimine reductase, which catalyzes the NAD(P)H-dependent reduction of -C=N- (imine) double bonds of a number of cyclic ketimine substrates including sulfur-containing cyclic ketimines, the enzyme has a biological function in its degradative role as a DELTA1-piperideine-2-carboxylate (P2C) reductase in the pipecolate pathway of lysine metabolism. The pipecolate pathway is the main L-lysine degradation pathway in the adult brain. Potent regulation of ketimine reductase activity by thyroid hormones | Homo sapiens |
physiological function | CRYM has the ability to strongly bind thyroid hormones in an NADPH-dependent fashion. CRYM is also an enzyme, namely ketimine reductase, which catalyzes the NAD(P)H-dependent reduction of -C=N- (imine) double bonds of a number of cyclic ketimine substrates including sulfur-containing cyclic ketimines, the enzyme has a biological function in its degradative role as a DELTA1-piperideine-2-carboxylate (P2C) reductase in the pipecolate pathway of lysine metabolism. The pipecolate pathway is the main L-lysine degradation pathway in the adult brain. Potent regulation of ketimine reductase activity by thyroid hormones | Rattus norvegicus |