Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition by caspase III inhibitor benzyloxycarbonyl-Asp(OMe)-fluoromethylketone | Amanita phalloides |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DL-asparagine + H2O + O2 | Amanita phalloides | low activity | 2-oxosuccinamic acid + NH3 + H2O2 | - |
? | |
DL-leucine + H2O + O2 | Amanita phalloides | - |
2-oxo-4-methylpentanoate + NH3 + H2O2 | - |
? | |
DL-methionine + H2O + O2 | Amanita phalloides | - |
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2 | - |
? | |
DL-norleucine + H2O + O2 | Amanita phalloides | - |
2-oxocaproate + NH3 + H2O2 | - |
? | |
DL-threonine + H2O + O2 | Amanita phalloides | low activity | 2-oxo-3-hydroxybutanoic acid + NH3 + H2O2 | - |
? | |
DL-tryptophan + H2O + O2 | Amanita phalloides | low activity | 3-(1H-indol-3-yl)-2-oxopropanoic acid + NH3 + H2O2 | - |
? | |
DL-valine + H2O + O2 | Amanita phalloides | low activity | 2-oxoisovalerate + NH3 + H2O2 | - |
? | |
L-arginine + H2O + O2 | Amanita phalloides | - |
2-oxo-5-guanidinopentanoic acid + NH3 + H2O2 | - |
? | |
L-glutamic acid + H2O + O2 | Amanita phalloides | low activity | 2-oxoglutarate + NH3 + H2O2 | - |
? | |
L-histidine + H2O + O2 | Amanita phalloides | low activity | 2-oxo-4-imidazolepropionic acid + NH3 + H2O2 | - |
? | |
L-isoleucine + H2O + O2 | Amanita phalloides | - |
3-methyl-2-oxopentanoate + NH3 + H2O2 | - |
? | |
L-lysine + H2O + O2 | Amanita phalloides | low activity | 6-amino-2-oxohexanoic acid + NH3 + H2O2 | - |
? | |
L-methionine + H2O + O2 | Amanita phalloides | preferred substrate | 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2 | - |
? | |
L-phenylalanine + H2O + O2 | Amanita phalloides | - |
phenylpyruvate + NH3 + H2O2 | - |
? | |
L-tyrosine + H2O + O2 | Amanita phalloides | - |
4-hydroxyphenylpyruvate + NH3 + H2O2 | - |
? | |
lysine + H2O + O2 | Amanita phalloides | low activity | 6-amino-2-oxohexanoic acid + NH3 + H2O2 | - |
? | |
additional information | Amanita phalloides | toxophallin induces chromatin condensation, as well as DNA and nucleus fragmentation, which are typical for apoptosis, effect towards human leukemia CEM-T4 and murine leukemia L1210 cells, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Amanita phalloides | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fruit body | - |
Amanita phalloides | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DL-asparagine + H2O + O2 | low activity | Amanita phalloides | 2-oxosuccinamic acid + NH3 + H2O2 | - |
? | |
DL-leucine + H2O + O2 | - |
Amanita phalloides | 2-oxo-4-methylpentanoate + NH3 + H2O2 | - |
? | |
DL-methionine + H2O + O2 | - |
Amanita phalloides | 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2 | - |
? | |
DL-norleucine + H2O + O2 | - |
Amanita phalloides | 2-oxocaproate + NH3 + H2O2 | - |
? | |
DL-threonine + H2O + O2 | low activity | Amanita phalloides | 2-oxo-3-hydroxybutanoic acid + NH3 + H2O2 | - |
? | |
DL-tryptophan + H2O + O2 | low activity | Amanita phalloides | 3-(1H-indol-3-yl)-2-oxopropanoic acid + NH3 + H2O2 | - |
? | |
DL-valine + H2O + O2 | low activity | Amanita phalloides | 2-oxoisovalerate + NH3 + H2O2 | - |
? | |
L-arginine + H2O + O2 | - |
Amanita phalloides | 2-oxo-5-guanidinopentanoic acid + NH3 + H2O2 | - |
? | |
L-glutamic acid + H2O + O2 | low activity | Amanita phalloides | 2-oxoglutarate + NH3 + H2O2 | - |
? | |
L-histidine + H2O + O2 | low activity | Amanita phalloides | 2-oxo-4-imidazolepropionic acid + NH3 + H2O2 | - |
? | |
L-isoleucine + H2O + O2 | - |
Amanita phalloides | 3-methyl-2-oxopentanoate + NH3 + H2O2 | - |
? | |
L-lysine + H2O + O2 | low activity | Amanita phalloides | 6-amino-2-oxohexanoic acid + NH3 + H2O2 | - |
? | |
L-methionine + H2O + O2 | preferred substrate | Amanita phalloides | 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2 | - |
? | |
L-phenylalanine + H2O + O2 | - |
Amanita phalloides | phenylpyruvate + NH3 + H2O2 | - |
? | |
L-tyrosine + H2O + O2 | - |
Amanita phalloides | 4-hydroxyphenylpyruvate + NH3 + H2O2 | - |
? | |
lysine + H2O + O2 | low activity | Amanita phalloides | 6-amino-2-oxohexanoic acid + NH3 + H2O2 | - |
? | |
additional information | toxophallin induces chromatin condensation, as well as DNA and nucleus fragmentation, which are typical for apoptosis, effect towards human leukemia CEM-T4 and murine leukemia L1210 cells, overview | Amanita phalloides | ? | - |
? | |
additional information | L-cysteine, L-glycine, L-proline, L-oxyproline, DL-serine, and DL-aspartic acid are no substrates. Toxophallin is also not active against benzylamine, ethanolamine, diethylamine, meta- and para-phenylendiamine, ortho-, meta- and paraaminophenols, or putrescin | Amanita phalloides | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | toxophallin peptide mapping and sequence analysis by MALDI-TOF mass spectrometry, overview | Amanita phalloides |
Synonyms | Comment | Organism |
---|---|---|
toxophallin | - |
Amanita phalloides |
General Information | Comment | Organism |
---|---|---|
additional information | toxophallin is a highly cytotoxic protein, but differs distinctly from the other death cap toxic protein phallolysin. The interaction of toxophallin with target cells is not mediated by a specific cell surface receptor | Amanita phalloides |
physiological function | toxophallin induces chromatin condensation, as well as DNA and nucleus fragmentation, which are typical for apoptosis. Toxophallin uses a caspase-independent pathway of apoptosis induction | Amanita phalloides |