Cloned (Comment) | Organism |
---|---|
expression of proenzyme, mature enzyme, isolated propeptide, and mutant enzymes in HEK-293 cells as HA-tagged proteins | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
K314A | site-directed mutagenesis | Mus musculus |
Y349F | site-directed mutagenesis | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | mature LOX and mature TGF-beta1 are colocalized in the extracellular matrix in an osteoblastic cell culture system | Mus musculus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | dependent on | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | lysyl oxidase, an amine oxidase, is critical for the initiation of collagen and elastin cross-linking, binds transforming growth factor-beta, and regulates its signaling via amine oxidase activity, mechanism, overview. LOX suppresses TGF-beta1-induced Smad3 phosphorylation likely through its amine oxidase activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone matrix | mineral-associated fraction | Mus musculus | - |
osteoblast cell line | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | lysyl oxidase, an amine oxidase, is critical for the initiation of collagen and elastin cross-linking, binds transforming growth factor-beta, and regulates its signaling via amine oxidase activity, mechanism, overview. LOX suppresses TGF-beta1-induced Smad3 phosphorylation likely through its amine oxidase activity | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LOX | - |
Mus musculus |
lysyl oxidase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.2 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme binds to mature TGF-beta1 and enzymatically regulates its signaling in bone and plays an important role in bone maintenance and remodeling | Mus musculus |