BRENDA - Enzyme Database show
show all sequences of 1.4.1.24

L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii

White, R.H.; Biochemistry 43, 7618-7627 (2004)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells
Methanocaldococcus jannaschii
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Methanocaldococcus jannaschii
P81230
-
-
Methanocaldococcus jannaschii DSM 2661
P81230
-
-
Purification (Commentary)
Commentary
Organism
heat precipitation and Sephadex G-25 gel filtration
Methanocaldococcus jannaschii
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate undergoes a NAD+-dependent oxidative deamination to produce 3,7-dideoxy-D-threo-hept-2,6-diulosonic acid which cyclizes to 3-dehydroquinate
718838
Methanocaldococcus jannaschii
3-dehydroquinate + NH3 + NADH + H+
-
-
-
?
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate undergoes a NAD+-dependent oxidative deamination to produce 3,7-dideoxy-D-threo-hept-2,6-diulosonic acid which cyclizes to 3-dehydroquinate
718838
Methanocaldococcus jannaschii DSM 2661
3-dehydroquinate + NH3 + NADH + H+
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells
Methanocaldococcus jannaschii
Purification (Commentary) (protein specific)
Commentary
Organism
heat precipitation and Sephadex G-25 gel filtration
Methanocaldococcus jannaschii
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate undergoes a NAD+-dependent oxidative deamination to produce 3,7-dideoxy-D-threo-hept-2,6-diulosonic acid which cyclizes to 3-dehydroquinate
718838
Methanocaldococcus jannaschii
3-dehydroquinate + NH3 + NADH + H+
-
-
-
?
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate undergoes a NAD+-dependent oxidative deamination to produce 3,7-dideoxy-D-threo-hept-2,6-diulosonic acid which cyclizes to 3-dehydroquinate
718838
Methanocaldococcus jannaschii DSM 2661
3-dehydroquinate + NH3 + NADH + H+
-
-
-
?
Other publictions for EC 1.4.1.24
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
743314
Zhi
Genome-wide identification, d ...
Frankia casuarinae, Stigmatella aurantiaca, Streptomyces griseus, Streptomyces griseus NBRC 13350, Streptomyces scabiei, Streptomyces scabiei 87.22
Mol. Phylogenet. Evol.
75
154-164
2014
-
-
-
-
-
-
-
-
-
-
-
12
-
6
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718845
Morar
Structure of 2-amino-3,7-dideo ...
Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661
Biochemistry
46
10562-10571
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718838
White
L-Aspartate semialdehyde and a ...
Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661
Biochemistry
43
7618-7627
2004
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-