Application | Comment | Organism |
---|---|---|
synthesis | inactivation of KstD isoforms 1-3 leads to synthesis of about 6.02g/l of 9alpha-hydroxy-4-androstene-3,17-dione from 15 g/l of phytosterols. The product is mixed with 1.55 g/l of 4-androstene-3,17-dione as a major byproduct. Overexpression of the oxygenase component of 3-ketosteroid-9alpha-hydroxylase kshA, results in a yield of 9alpha-hydroxy-4-androstene-3,17-dione of 7.33 g/l | Mycolicibacterium neoaurum |
Cloned (Comment) | Organism |
---|---|
- |
Mycolicibacterium neoaurum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.011 | - |
4-androstene-17beta-ol-3-one | pH 7.0, 30°C | Mycolicibacterium neoaurum | |
0.025 | - |
4-androstene-3,17-dione | pH 7.0, 30°C | Mycolicibacterium neoaurum | |
0.025 | - |
9alpha-hydroxy-4-androstene-3,17-dione | pH 7.0, 30°C | Mycolicibacterium neoaurum | |
0.035 | - |
5alpha-androstane-17beta-ol-3-one | pH 7.0, 30°C | Mycolicibacterium neoaurum | |
0.0379 | - |
5alpha-androstane-17beta-ol-3-one | pH 7.0, 30°C | Mycolicibacterium neoaurum | |
0.039 | - |
progesterone | pH 7.0, 30°C | Mycolicibacterium neoaurum | |
0.045 | - |
9alpha-hydroxy-4-androstene-3,17-dione | pH 7.0, 30°C | Mycolicibacterium neoaurum | |
0.06 | - |
progesterone | pH 7.0, 30°C | Mycolicibacterium neoaurum | |
0.065 | - |
4-androstene-3,17-dione | pH 7.0, 30°C | Mycolicibacterium neoaurum | |
0.082 | - |
4-androstene-17beta-ol-3-one | pH 7.0, 30°C | Mycolicibacterium neoaurum | |
0.085 | - |
4-androstene-17beta-ol-3-one | pH 7.0, 30°C | Mycolicibacterium neoaurum | |
0.105 | - |
9alpha-hydroxy-4-androstene-3,17-dione | pH 7.0, 30°C | Mycolicibacterium neoaurum | |
0.125 | - |
progesterone | pH 7.0, 30°C | Mycolicibacterium neoaurum | |
0.16 | - |
4-androstene-3,17-dione | pH 7.0, 30°C | Mycolicibacterium neoaurum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycolicibacterium neoaurum | C8CJG6 | isoform KstD1 | - |
Mycolicibacterium neoaurum | W0NR13 | isoform KstD2 | - |
Mycolicibacterium neoaurum | W0NUN5 | isoform KstD3 | - |
Mycolicibacterium neoaurum ATCC 25795 | C8CJG6 | isoform KstD1 | - |
Mycolicibacterium neoaurum ATCC 25795 | W0NR13 | isoform KstD2 | - |
Mycolicibacterium neoaurum ATCC 25795 | W0NUN5 | isoform KstD3 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-androstene-17beta-ol-3-one + 2,6-dichlorophenol-indophenol | - |
Mycolicibacterium neoaurum | 1,4-androstadiene-17beta-ol-3-one + reduced 2,6-dichlorophenol-indophenol | - |
? | |
4-androstene-17beta-ol-3-one + 2,6-dichlorophenol-indophenol | - |
Mycolicibacterium neoaurum ATCC 25795 | 1,4-androstadiene-17beta-ol-3-one + reduced 2,6-dichlorophenol-indophenol | - |
? | |
4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol | - |
Mycolicibacterium neoaurum | 1,4-androstadiene-3,17-dione + reduced 2,6-dichlorophenol-indophenol | - |
? | |
4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol | - |
Mycolicibacterium neoaurum ATCC 25795 | 1,4-androstadiene-3,17-dione + reduced 2,6-dichlorophenol-indophenol | - |
? | |
5alpha-androstane-17beta-ol-3-one + 2,6-dichlorophenol-indophenol | - |
Mycolicibacterium neoaurum | 5alpha-androst-1-ene-17beta-ol-3-one + reduced 2,6-dichlorophenol-indophenol | - |
? | |
5alpha-androstane-17beta-ol-3-one + 2,6-dichlorophenol-indophenol | - |
Mycolicibacterium neoaurum ATCC 25795 | 5alpha-androst-1-ene-17beta-ol-3-one + reduced 2,6-dichlorophenol-indophenol | - |
? | |
9alpha-hydroxy-4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol | - |
Mycolicibacterium neoaurum | 9alpha-hydroxyandrost-1,4-diene-3,17-dione + reduced 2,6-dichlorophenol-indophenol | - |
? | |
9alpha-hydroxy-4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol | - |
Mycolicibacterium neoaurum ATCC 25795 | 9alpha-hydroxyandrost-1,4-diene-3,17-dione + reduced 2,6-dichlorophenol-indophenol | - |
? | |
progesterone + 2,6-dichlorophenol-indophenol | - |
Mycolicibacterium neoaurum | pregna-1,4-diene-3,20-dione + reduced 2,6-dichlorophenol-indophenol | - |
? | |
progesterone + 2,6-dichlorophenol-indophenol | - |
Mycolicibacterium neoaurum ATCC 25795 | pregna-1,4-diene-3,20-dione + reduced 2,6-dichlorophenol-indophenol | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 61000, calculated | Mycolicibacterium neoaurum |
? | x * 54300, calculated | Mycolicibacterium neoaurum |
? | x * 60100, calculated | Mycolicibacterium neoaurum |
Synonyms | Comment | Organism |
---|---|---|
KSTD1 | - |
Mycolicibacterium neoaurum |
KSTD2 | - |
Mycolicibacterium neoaurum |
KSTD3 | - |
Mycolicibacterium neoaurum |