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Literature summary for 1.3.8.7 extracted from
- Inactivation of medium-chain acyl-CoA dehydrogenase by oct-4-en-2-ynoyl-CoA (2006), Bioorg. Med. Chem. Lett., 16, 1445-1448.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | inhibitor may become a lead for further development for treating non-insulin-dependent diabetes mellitus | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not inhibited by trans-2,trans-4-octadienoyl-CoA and oct-2-en-4-ynoyl-CoA | Rattus norvegicus | |
| oct-4-en-2-ynoyl-CoA | irreversible inhibitor, active-site directed, enzyme protected by 2-octenoyl-CoA | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol | - |
Rattus norvegicus | 2-octenoyl-CoA + reduced acceptor | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MCAD | - |
Rattus norvegicus |
| medium chain-specific acyl-CoA oxidase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | is not the target of the inhibitor | Rattus norvegicus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.011 | - |
oct-4-en-2-ynoyl-CoA | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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