Inhibitors | Comment | Organism | Structure |
---|---|---|---|
20-piperidin-2-yl-5alpha-pregnan-20(R),3beta-diol | i.e. AZA-1, inhibits the enzyme and the DELTA24-sterol methyltransferase, leads to accumulation of ergosta-5,7,24(28)-trien-3beta-ol in vivo | Paracoccidioides brasiliensis | |
22-piperidin-2-yl-5alpha-pregnan-3beta,22(S)-diol | i.e. AZA-2, specific inhibition of the enzyme, leads to accumulatin of ergosta-5,7,22,24(28)-tetraen-3beta-ol in vivo | Paracoccidioides brasiliensis | |
22-piperidin-3-yl-5alpha-pregnan-3beta,22(S)-diol | i.e. AZA-3, inhibits the enzyme, major proliferative effect and accumulation of lanosterol in vivo | Paracoccidioides brasiliensis | |
additional information | sterol composition with or without addition of azasterol analogue inhibitors, overview | Paracoccidioides brasiliensis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH | Paracoccidioides brasiliensis | step in the biosynthesis of ergosta-5,22-dien-3bta-ol, i.e. brassicasterol, the major sterol compound in Paracoccidioides brasiliensis | ergosterol + NADP+ | - |
? | |
additional information | Paracoccidioides brasiliensis | sterol composition with or without addition of azasterol analogue inhibitors, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Paracoccidioides brasiliensis | - |
dimorphic fungus | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | organism in its pathogenic yeast-like phase | Paracoccidioides brasiliensis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH | - |
Paracoccidioides brasiliensis | ergosterol + NADP+ | - |
? | |
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH | step in the biosynthesis of ergosta-5,22-dien-3bta-ol, i.e. brassicasterol, the major sterol compound in Paracoccidioides brasiliensis | Paracoccidioides brasiliensis | ergosterol + NADP+ | - |
? | |
additional information | sterol composition with or without addition of azasterol analogue inhibitors, overview | Paracoccidioides brasiliensis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DELTA24(28)-sterol methylreductase | - |
Paracoccidioides brasiliensis |
SMR | - |
Paracoccidioides brasiliensis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Paracoccidioides brasiliensis |