Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of gene Tm7sf2 knockout mice | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q71KT5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
3 beta-hydroxysterol-DELTA14-reductase | - |
Mus musculus |
3beta-hydroxysterol DELTA14-reductase | - |
Mus musculus |
C14-SR | - |
Mus musculus |
TM7SF2 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | Tm7sf2 deficiency during liver regeneration alters lipid metabolism and generates a stress condition, which, in turn, transiently unbalances hepatocytes cell cycle progression. Tm7sf2 knockout mice show no alteration in cholesterol content, but accumulation and delayed catabolism of hepatic triglycerides is observed, resulting in persistent steatosis at all times post hepatectomy. Delayed cell cycle progression to the G1/S phase is observed in Tm7sf2 knockout mice, resulting in reduced cell division at the time points examined associated to abnormal endoplasmic reticulum stress response, leading to alteration in p53 content and, consequently, induction of p21 expression in Tm7sf2 knockout mice. Tm7sf2 knockout mice exhibit a high-degree of transient hepatic steatosis during liver regeneration after partial hepatectomy. Hepatocytes from Tm7sf2 KO mice have a defective progression through the G1/S phase, associated to delayed and/or reduced expression of central regulators of the cell cycle such as cyclin D1, cyclin A, cyclin E1 and CDK4 | Mus musculus |
physiological function | the enzyme catalyzes the reduction of C14-unsaturated sterols during cholesterol biosynthesis from lanosterol. Role of C14-SR in vivo during cell proliferation by evaluating liver regeneration in Tm7sf2 knockout and wild-type mice, overview | Mus musculus |