Crystallization (Comment) | Organism |
---|---|
structure of SRD5A in complex with NADPH at 2.0 A resolution. SRD5A exists as a monomer comprised of seven transmembrane segments (TMs). The TM1-4 enclose a hydrophobic substrate binding cavity, whereas TM5-7 coordinate cofactor NADPH through extensive hydrogen bonds network | Proteobacteria bacterium |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dutasteride | - |
Proteobacteria bacterium |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
27500 | - |
analytical ultracentrifugation | Proteobacteria bacterium |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Proteobacteria bacterium | A0A3A0FWV3 | - |
- |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 29000, calculated from sequence | Proteobacteria bacterium |
Synonyms | Comment | Organism |
---|---|---|
DCC71_03205 | - |
Proteobacteria bacterium |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0016 | - |
pH 7.4, 37°C | Proteobacteria bacterium | dutasteride |