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Literature summary for 1.20.4.1 extracted from

  • Gregus, Z.; Nemeti, B.
    The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase works as an arsenate reductase in human red blood cells and rat liver cytosol (2005), Toxicol. Sci., 85, 859-869.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ADP moderate Homo sapiens
ADP moderate Rattus norvegicus
ATP moderate Homo sapiens
ATP moderate Rattus norvegicus
Koningic acid inhibition of both classical enzymic and arsentate reductase activities of glyceraldehyde-3-phosphate dehydrogenase Homo sapiens
Koningic acid inhibition of both classical enzymic and arsentate reductase activities of glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus
NADH strong Homo sapiens
NADH strong Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol besides glyceraldehyde-3-phosphate dehydrogenase, presence of other enzymes contributing to arsenate reduction Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
glyceraldehyde-3-phosphate dehydrogenase working as arsenate reductase
-
Rattus norvegicus
-
glyceraldehyde-3-phosphate dehydrogenase working as arsenate reductase
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arsenate + reduced glutathione + NAD+ + glyceraldehyde-3-phosphate
-
Homo sapiens arsenite + glutathione + ?
-
?
arsenate + reduced glutathione + NAD+ + glyceraldehyde-3-phosphate
-
Rattus norvegicus arsenite + glutathione + ?
-
?