Literature summary for 1.2.5.3 extracted from

Hollingsworth, T.S.; Hollingsworth, R.L.; Lord, R.L.; Groysman, S.
Cooperative bimetallic reactivity of a heterodinuclear molybdenum-copper model of Mo-Cu CODH (2018), Dalton Trans., 47, 10017-10024 .

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Organism

Organism	UniProt	Comment	Textmining
synthetic construct	-	-	-

General Information

General Information	Comment	Organism
physiological function	the heterodinucleating ligand LH2, i.e. (E)-3-(((2,7-di-tert-butyl-9,9-dimethyl-5-((pyridin-2-ylmethylene)amino)-9H-xanthen-4-yl)amino)methyl)benzene-1,2-diol functions as functional model of the bimetallic active site found in Mo-Cu carbon monoxide dehydrogenase. Treatment of LH2 with either Cu(I) or M(VI) (M = Mo, W) sources leads to the site-selective incorporation of the respective metals. The incorporation of both Mo(VI) and Cu(I) into L forms a highly reactive heterobimetallic complex [MoVIO3CuI(L)](NEt4)2, that triggers oxidation reactivity, in which a nucleophilic Mo(VI) trioxo attacks Cu(I)-bound imine. The major product of the reaction is a molybdenum(VI) complex [Mo(L')O2](NEt4) coordinated by a modified ligand L' that contains a new C-O bond in place of the imine functionality	synthetic construct

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Release 2023.1 (January 2023)