Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trimethylaminobutyraldehyde + NAD+ + H2O | Rattus norvegicus | enzyme is involved in L-carnitine (3-hydroxy-4-N-trimethylaminobutyrate) biosynthesis | gamma-butyrobetaine + NADH + 2 H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q9JLJ3 | foetuses, newborn, suckling, weaning and adult rats | - |
Rattus norvegicus | Q9JLJ3 | male Wister rat | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
renal cortex | - |
Rattus norvegicus | - |
renal medulla | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
expression of TMABA-DH is ontogenically regulated, renal levels of TMABA-DH are quantified by real-time PCR assays in foetuses, newborn, suckling, weaning and 2-month-old rats, foetuses express TMABA-DH mRNA and this expression increases significantly with maturation, comparisons between cortex and medulla reveals that, except for foetuses and newborn rats, TMABA-DHmRNA levels are significantly higher in the medulla than in the cortex | Rattus norvegicus |
additional information | - |
levels of liver mRNA TMABA-DH are approximately 2times greater than the maximal values measured in kidneys | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trimethylaminobutyraldehyde + NAD+ + H2O | enzyme is involved in L-carnitine (3-hydroxy-4-N-trimethylaminobutyrate) biosynthesis | Rattus norvegicus | gamma-butyrobetaine + NADH + 2 H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
4-trimethylammoniobutyraldehyde dehydrogenase | - |
Rattus norvegicus |
gamma-trimethylaminobutyraldehyde dehydrogenase | - |
Rattus norvegicus |
TMABA-DH | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | detection of mRNA levels in foetuses, increase during postnatal life, expression is ontogenically regulated | up |