Inhibitors | Comment | Organism | Structure |
---|---|---|---|
gemcitabine | - |
Homo sapiens | |
additional information | no enzyme inhibition by arabinoside cytosine | Homo sapiens | |
triapine | i.e. 3-AP, triapine enhances the cytotoxicity of gemcitabine and arabinoside cytosine in four non-small-cell-lung-cancer cell lines, e.g. in SW1573 cells, but not in H460 cells, multiple-drug-effect analysis, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
additional information | RNR expression in small cell lung cancer cell lines, overview | Homo sapiens | - |
NCI-H292 cell | - |
Homo sapiens | - |
NCI-H460 cell | - |
Homo sapiens | - |
SW-1573 cell | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
tetramer | RNR is a tetramer consisting of two non-identical homodimers. The two identical M2 subunits regulate the substrate specificity of the enzyme, while the other two identical M1 subunits are responsible for the activity by binding the ribonucleotides and allosteric effectors | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
RNR | - |
Homo sapiens |