Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dATP | 0.2-0.4 mM, induces formation of dimers and tetramers of subunit R1, 1-2 mM, induces formation of hexamers of subunit R1 | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ribonucleoside diphosphate + reduced thioredoxin | CDP is the only substrate that is reduced with a significant activity even in the absence of allosteric effectors | Mus musculus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | nucleotide binding to the specificity site drives formation of an active R1,2R2,2 dimer, ATP or dATP binding to the adenine-specific site results in formation of an inactive tetramer and ATP binding to the hexamerization site drives formation of an active R1,6R2,6 hexamer which is probably the major active form in mammalian cells | Mus musculus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.047 | - |
CDP | CDP reduction in the absence of allosteric effectors | Mus musculus | |
0.16 | - |
CDP | CDP reduction in the presence of 1 mM ATP | Mus musculus | |
0.26 | - |
CDP | CDP reduction in the presence of 0.2 mM ATP | Mus musculus | |
0.29 | - |
CDP | CDP reduction in the presence of 4 mM ATP | Mus musculus |