Literature summary for 1.17.1.9 extracted from

Raaijmakers, H.C.; Romao, M.J.
Formate-reduced E. coli formate dehydrogenase H: The reinterpretation of the crystal structure suggests a new reaction mechanism (2006), J. Biol. Inorg. Chem., 11, 849-854.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
re-evaluation of crystallographic data	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P07658	isoform H	-

Reaction

Reaction	Comment	Organism	Reaction ID
formate + NAD+ = CO2 + NADH + H+	reaction mechanism: step I, formate binds directly to Mo, displacing Se-Cys140. Step II, the alpha-proton from formate may be transferred to the nearby His141 that acts as general base. Alternatively, step II may involve a selenium-carboxylated intermediate. Step III, electrons from MoIV are transferred via the 4Fe-4S center to an external electron acceptor and the catalytic cycle is completed	Escherichia coli	a

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Release 2023.1 (January 2023)