KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.44 | - |
N4-hydroxycytidine | pH 6.0, 37°C | Homo sapiens | |
0.52 | - |
N4-hydroxycytosine | pH 6.0, 37°C | Homo sapiens | |
0.72 | - |
N6-hydroxyadenine | pH 6.0, 37°C | Homo sapiens | |
0.77 | - |
N6-hydroxyadenine | pH 6.0, 37°C | Homo sapiens | |
0.98 | - |
N6-hydroxyadenosine | pH 6.0, 37°C | Homo sapiens | |
1.5 | 2 | N4-hydroxycytosine | pH 6.0, 37°C | Homo sapiens | |
5.28 | - |
N6-hydroxyadenosine | pH 6.0, 37°C | Homo sapiens | |
5.65 | - |
N4-hydroxycytidine | pH 6.0, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q5VT66 | isoform mARC1 | - |
Homo sapiens | Q969Z3 | isoform mARC2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
additional information | activity is found in all tested tissues with the highest detectable conversion rates in liver, kidney, thyroid, and pancreas | Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
thyroid gland | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0396 | - |
substrate N4-hydroxycytosine, pH 6.0, 37°C | Homo sapiens |
0.0502 | - |
substrate N4-hydroxycytidine, pH 6.0, 37°C | Homo sapiens |
0.1031 | - |
substrate N4-hydroxycytidine, pH 6.0, 37°C | Homo sapiens |
0.105 | - |
substrate N6-hydroxyadenosine, pH 6.0, 37°C | Homo sapiens |
0.1189 | - |
substrate N4-hydroxycytosine, pH 6.0, 37°C | Homo sapiens |
0.133 | - |
substrate N6-hydroxyadenine, pH 6.0, 37°C | Homo sapiens |
0.142 | - |
substrate benzamidoxime, pH 6.0, 37°C | Homo sapiens |
0.1594 | - |
substrate benzamidoxime, pH 6.0, 37°C | Homo sapiens |
0.1808 | - |
substrate N6-hydroxyadenine, pH 6.0, 37°C | Homo sapiens |
0.2202 | - |
substrate N6-hydroxyadenosine, pH 6.0, 37°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 [Fe(II)-cytochrome b5] + 2 H+ + benzamidoxime | - |
Homo sapiens | 2 [Fe(III)-cytochrome b5] + H2O + benzamidine | - |
? | |
2 [Fe(II)-cytochrome b5] + 2 H+ + N4-hydroxycytidine | - |
Homo sapiens | 2 [Fe(III)-cytochrome b5] + H2O + cytidine | - |
? | |
2 [Fe(II)-cytochrome b5] + 2 H+ + N4-hydroxycytosine | - |
Homo sapiens | 2 [Fe(III)-cytochrome b5] + H2O + cytosine | - |
? | |
2 [Fe(II)-cytochrome b5] + 2 H+ + N6-hydroxyadenine | - |
Homo sapiens | 2 [Fe(III)-cytochrome b5] + H2O + adenine | - |
? | |
2 [Fe(II)-cytochrome b5] + 2 H+ + N6-hydroxyadenosine | - |
Homo sapiens | 2 [Fe(III)-cytochrome b5] + H2O + adenosine | - |
? |
General Information | Comment | Organism |
---|---|---|
metabolism | both mARC isoforms are able to reduce N-hydroxylated base analogues, with mARC1 representing the more efficient isoform | Homo sapiens |