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Literature summary for 1.16.98.B1 extracted from

  • Kotthaus, J.; Wahl, B.; Havemeyer, A.; Kotthaus, J.; Schade, D.; Garbe-Schönberg, D.; Mendel, R.; Bittner, F.; Clement, B.
    Reduction of N(omega)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC) (2011), Biochem. J., 433, 383-391 .
    View publication on PubMed
Search for more literature for 1.16.98.B1

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.18
-
 benzamidoxime pH 6.0, 37°C Homo sapiens
0.83
-
 benzamidoxime pH 6.0, 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 [Fe(II)-cytochrome b5] + 2 H+ + Nomega-hydroxy-L-arginine Homo sapiens
-
 2 [Fe(III)-cytochrome b5] + H2O + L-arginine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5VT66 isoform mARC1
-
Homo sapiens Q969Z3 isoform mARC2
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0343
-
 substrate benzamidoxime, pH 6.0, 37°C Homo sapiens
0.0907
-
 substrate benzamidoxime, pH 6.0, 37°C Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 [Fe(II)-cytochrome b5] + 2 H+ + benzamidoxime
-
 Homo sapiens 2 [Fe(III)-cytochrome b5] + H2O + benzamidine
-
 ?
2 [Fe(II)-cytochrome b5] + 2 H+ + Nomega-hydroxy-L-arginine
-
 Homo sapiens 2 [Fe(III)-cytochrome b5] + H2O + L-arginine
-
 ?
2 [Fe(II)-cytochrome b5] + 2 H+ + Nomega-hydroxy-Ndelta-methyl-L-arginine
-
 Homo sapiens 2 [Fe(III)-cytochrome b5] + H2O + N-delta-methyl-L-arginine
-
 ?

General Information

General Information Comment Organism
metabolism both isoforms mARC1 and mARC2 enhance the rate of reduction of Nomega-hydroxy-L-arginine, in the presence of NADH cytochrome b5 reductase and cytochrome b5, by more than 500fold Homo sapiens